A Kelch domain-containing KLHDC7B and a long non-coding RNA ST8SIA6-AS1 act oppositely on breast cancer cell proliferation via the interferon signaling pathway

• Published in: Scientific reports 2018-08, Vol.8 (1), p.12922-10, Article 12922
• Main Authors: Jeong, Gookjoo, Bae, Hansol, Jeong, Dawoon, Ham, Juyeon, Park, Sungbin, Kim, Hyeon Woo, Kang, Han-Sung, Kim, Sun Jung
• Format: Article
• Language: English
• Subjects: 13; 13/2; 13/95; 38; 38/77; 38/89; 45; 45/61; 631/337/384/2568; 631/67/1347; Adaptor Proteins, Signal Transducing; Apoptosis; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell adhesion & migration; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell Movement - physiology; Cell proliferation; Cell Proliferation - genetics; Cell Proliferation - physiology; Flow Cytometry; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Genes; Humanities and Social Sciences; Humans; Interferon; Interferons - genetics; Interferons - metabolism; Interleukins - genetics; Interleukins - metabolism; MCF-7 Cells; multidisciplinary; Non-coding RNA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA-Binding Proteins; Science; Science (multidisciplinary); Signal transduction; Signal Transduction - genetics; Signal Transduction - physiology; STAT Transcription Factors - genetics; STAT Transcription Factors - metabolism; Tumorigenesis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-31306-8

In our previous study, the Kelch domain-containing 7B (KLHDC7B) was revealed to be hypermethylated at the promoter but upregulated in breast cancer. In this study, we identified a long non-coding RNA, ST8SIA6-AS1 (STAR1), whose expression was significantly associated with KLHDC7B in breast cancer ( R 2  = 0.3466, P