Relationship between Serum Osteocalcin and Carotid Atherosclerosis in Middle-Aged Men in China: A Cross-Sectional Study

Background and Purpose. Numerous investigations found that there exists a close relationship between serum osteocalcin and incurrence of atherosclerosis, but studies investigating the effect of serum osteocalcin on carotid atherosclerosis are very limited. Our study is aimed at investigating the rol...

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Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-6
Main Authors: Cao, Juan, Li, Lingling, Dai, Yang, Lu, Hao, Deng, Hui, Zhu, Dalong
Format: Article
Language:English
Subjects:
Adult
Age
Alcohol
Analysis
Arteriosclerosis
Atherosclerosis
Biocompatibility
Blood pressure
Calcification
Cardiovascular disease
Carotid Artery Diseases - blood
Carotid Intima-Media Thickness
China
Cross-Sectional Studies
Diabetes
Endocrinology
Fins
Fractures
Gene expression
Humans
Hypertension
Laboratory tests
Male
Medical research
Medicine, Experimental
Metabolism
Middle Aged
Osteocalcin
Osteocalcin - blood
Regression analysis
Risk Factors
Smoking
Standard deviation
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container_title BioMed research international
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creator Cao, Juan
Li, Lingling
Dai, Yang
Lu, Hao
Deng, Hui
Zhu, Dalong
description Background and Purpose. Numerous investigations found that there exists a close relationship between serum osteocalcin and incurrence of atherosclerosis, but studies investigating the effect of serum osteocalcin on carotid atherosclerosis are very limited. Our study is aimed at investigating the role of osteocalcin in carotid atherosclerosis in middle-aged men in China. Methods. A total of 335 male middle-aged participants (40-60, 52.4 ± 3.87 years averagely) were enrolled from the institute. The carotid intima-media thicknesses (CIMT) of each subject were measured. All subjects were included either in the carotid atherosclerosis (AS) group or the control group according to the CAS diagnosis criteria. Serum osteocalcin and other markers of each patient were assessed following standard laboratory tests protocol. Results. 135 subjects were included in AS group, and 199 subjects were included in control group. The average osteocalcin level in AS group was 18.71 ± 6.20 ng/ml and was significantly different from that in control group, which was 20.38 ± 7.19 ng/ml (p=0.039). Logistic regression analysis revealed that OCN (standardized β=-0.024, p=0.013) and FINS (standardized β=-0.065, p=0.010) were independently and inversely associated with the carotid atherosclerosis, while FPG (standardized β=0.538, p=0.006) was independently and positively associated with the carotid atherosclerosis. Conclusion. Our study suggests that OCN is independently related to carotid atherosclerosis in middle-aged male individuals.
doi_str_mv 10.1155/2018/1751905
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Numerous investigations found that there exists a close relationship between serum osteocalcin and incurrence of atherosclerosis, but studies investigating the effect of serum osteocalcin on carotid atherosclerosis are very limited. Our study is aimed at investigating the role of osteocalcin in carotid atherosclerosis in middle-aged men in China. Methods. A total of 335 male middle-aged participants (40-60, 52.4 ± 3.87 years averagely) were enrolled from the institute. The carotid intima-media thicknesses (CIMT) of each subject were measured. All subjects were included either in the carotid atherosclerosis (AS) group or the control group according to the CAS diagnosis criteria. Serum osteocalcin and other markers of each patient were assessed following standard laboratory tests protocol. Results. 135 subjects were included in AS group, and 199 subjects were included in control group. The average osteocalcin level in AS group was 18.71 ± 6.20 ng/ml and was significantly different from that in control group, which was 20.38 ± 7.19 ng/ml (p=0.039). Logistic regression analysis revealed that OCN (standardized β=-0.024, p=0.013) and FINS (standardized β=-0.065, p=0.010) were independently and inversely associated with the carotid atherosclerosis, while FPG (standardized β=0.538, p=0.006) was independently and positively associated with the carotid atherosclerosis. Conclusion. Our study suggests that OCN is independently related to carotid atherosclerosis in middle-aged male individuals.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/1751905</identifier><identifier>PMID: 30186852</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Age ; Alcohol ; Analysis ; Arteriosclerosis ; Atherosclerosis ; Biocompatibility ; Blood pressure ; Calcification ; Cardiovascular disease ; Carotid Artery Diseases - blood ; Carotid Intima-Media Thickness ; China ; Cross-Sectional Studies ; Diabetes ; Endocrinology ; Fins ; Fractures ; Gene expression ; Humans ; Hypertension ; Laboratory tests ; Male ; Medical research ; Medicine, Experimental ; Metabolism ; Middle Aged ; Osteocalcin ; Osteocalcin - blood ; Regression analysis ; Risk Factors ; Smoking ; Standard deviation</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-6</ispartof><rights>Copyright © 2018 Hui Deng et al.</rights><rights>COPYRIGHT 2018 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2018 Hui Deng et al. 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Numerous investigations found that there exists a close relationship between serum osteocalcin and incurrence of atherosclerosis, but studies investigating the effect of serum osteocalcin on carotid atherosclerosis are very limited. Our study is aimed at investigating the role of osteocalcin in carotid atherosclerosis in middle-aged men in China. Methods. A total of 335 male middle-aged participants (40-60, 52.4 ± 3.87 years averagely) were enrolled from the institute. The carotid intima-media thicknesses (CIMT) of each subject were measured. All subjects were included either in the carotid atherosclerosis (AS) group or the control group according to the CAS diagnosis criteria. Serum osteocalcin and other markers of each patient were assessed following standard laboratory tests protocol. Results. 135 subjects were included in AS group, and 199 subjects were included in control group. 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Numerous investigations found that there exists a close relationship between serum osteocalcin and incurrence of atherosclerosis, but studies investigating the effect of serum osteocalcin on carotid atherosclerosis are very limited. Our study is aimed at investigating the role of osteocalcin in carotid atherosclerosis in middle-aged men in China. Methods. A total of 335 male middle-aged participants (40-60, 52.4 ± 3.87 years averagely) were enrolled from the institute. The carotid intima-media thicknesses (CIMT) of each subject were measured. All subjects were included either in the carotid atherosclerosis (AS) group or the control group according to the CAS diagnosis criteria. Serum osteocalcin and other markers of each patient were assessed following standard laboratory tests protocol. Results. 135 subjects were included in AS group, and 199 subjects were included in control group. The average osteocalcin level in AS group was 18.71 ± 6.20 ng/ml and was significantly different from that in control group, which was 20.38 ± 7.19 ng/ml (p=0.039). Logistic regression analysis revealed that OCN (standardized β=-0.024, p=0.013) and FINS (standardized β=-0.065, p=0.010) were independently and inversely associated with the carotid atherosclerosis, while FPG (standardized β=0.538, p=0.006) was independently and positively associated with the carotid atherosclerosis. Conclusion. Our study suggests that OCN is independently related to carotid atherosclerosis in middle-aged male individuals.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30186852</pmid><doi>10.1155/2018/1751905</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1064-1261</orcidid><oa>free_for_read</oa></addata></record>
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source Wiley-Blackwell Open Access Collection; Publicly Available Content Database
subjects Adult
Age
Alcohol
Analysis
Arteriosclerosis
Atherosclerosis
Biocompatibility
Blood pressure
Calcification
Cardiovascular disease
Carotid Artery Diseases - blood
Carotid Intima-Media Thickness
China
Cross-Sectional Studies
Diabetes
Endocrinology
Fins
Fractures
Gene expression
Humans
Hypertension
Laboratory tests
Male
Medical research
Medicine, Experimental
Metabolism
Middle Aged
Osteocalcin
Osteocalcin - blood
Regression analysis
Risk Factors
Smoking
Standard deviation
title Relationship between Serum Osteocalcin and Carotid Atherosclerosis in Middle-Aged Men in China: A Cross-Sectional Study
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