Clinical analysis of 86 botulism cases caused by cosmetic injection of botulinum toxin (BoNT)

This study was conducted to analyze the clinical characteristics of and treatment strategies for botulism among patients receiving cosmetic injection of botulinum toxin (BoNT).A total of 86 botulism patients caused by cosmetic injection of BoNT were enrolled in our study. All of the patients were di...

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Bibliographic Details
Published in:Medicine (Baltimore) 2018-08, Vol.97 (34), p.e10659-e10659
Main Authors: Bai, Lili, Peng, Xiaobo, Liu, Yanqing, Sun, Yawei, Wang, Xin, Wang, Xingwang, Lin, Guodong, Zhang, Peng, Wan, Kun, Qiu, Zewu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Botulinum Antitoxin - administration & dosage
Botulinum Antitoxin - therapeutic use
Botulinum Toxins - adverse effects
Botulism - chemically induced
Botulism - drug therapy
Cosmetics - adverse effects
Female
Humans
Immunologic Factors - administration & dosage
Immunologic Factors - therapeutic use
Injections
Middle Aged
Observational Study
Treatment Outcome
Young Adult
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Summary:This study was conducted to analyze the clinical characteristics of and treatment strategies for botulism among patients receiving cosmetic injection of botulinum toxin (BoNT).A total of 86 botulism patients caused by cosmetic injection of BoNT were enrolled in our study. All of the patients were diagnosed according to their history of cosmetic BoNT injection, clinical symptoms and signs, and other auxiliary examinations (including those on renal and liver functions, blood index detection, and chest X-ray). All of the patients received comprehensive treatments and botulinum antitoxin serum injection.The main symptoms of botulism patients included headache, dizziness, insomnia, fatigue, blurred vision, eye opening difficulty, slurred speech, dysphagia, bucking, constipation, and anxiety. These clinical symptoms occurred 0∼36 days after BoNT injection, especially from 2nd to 6th day after the operation. Furthermore, the usage dose of BoNT was negatively related to latent period. Finally, patients all discharged from our hospital 1∼20 days after treatments, and their symptoms relieved or disappeared.Botulism is a severe side effect for BoNT injection. Injecting botulinum antitoxin serum may be an effective approach to improve clinical outcomes of botulism cases.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000010659