Stereotactic radiosurgery (SRS) alone versus whole brain radiotherapy plus SRS in patients with 1 to 4 brain metastases from non-small cell lung cancer stratified by the graded prognostic assessment: A meta-analysis (PRISMA) of randomized control trials

The present study aims to assess the therapeutic effect of whole brain radiotherapy (WBRT) for brain metastases from non-small cell lung cancer stratified by graded prognostic assessment (GPA) through meta-analysis. The Cochrane Library, PubMed, Ovid (Elsevier) were retrieved. The included randomize...

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Bibliographic Details
Published in:Medicine (Baltimore) 2018-08, Vol.97 (33), p.e11777-e11777
Main Authors: Qie, Shuai, Li, Yanhong, Shi, Hong-yun, Yuan, Lanhui, Su, Lei, Zhang, Xi
Format: Article
Language:English
Subjects:
Brain - pathology
Brain - radiation effects
Brain Neoplasms - pathology
Brain Neoplasms - radiotherapy
Brain Neoplasms - secondary
Carcinoma, Non-Small-Cell Lung - pathology
Cranial Irradiation - methods
Disease-Free Survival
Humans
Lung Neoplasms - pathology
Neoplasm Metastasis
Prognosis
Radiosurgery - methods
Randomized Controlled Trials as Topic
Salvage Therapy - methods
Systematic Review and Meta-Analysis
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Summary:The present study aims to assess the therapeutic effect of whole brain radiotherapy (WBRT) for brain metastases from non-small cell lung cancer stratified by graded prognostic assessment (GPA) through meta-analysis. The Cochrane Library, PubMed, Ovid (Elsevier) were retrieved. The included randomized controlled trials (RCT) were evaluated, and the statistical analysis was performed using RevMan 5.3 software. Cochrane handbook was applied to evaluate the methodological quality. Statistical significance was considered as P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000011777