Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress

Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activatio...

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Bibliographic Details
Published in:Cell death and differentiation 2018-08, Vol.25 (8), p.1530-1531
Main Authors: Lam, Mable, Lawrence, David A., Ashkenazi, Avi, Walter, Peter
Format: Article
Language:English
Subjects:
631/80/470
631/80/474/1768
96
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Apoptosis
Biochemistry
Biomedical and Life Sciences
Caspase
Caspase-8
Cell Biology
Cell Cycle Analysis
Correspondence
Death receptors
Endoplasmic reticulum
Life Sciences
Stem Cells
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Summary:Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activation upon ER stress.
ISSN:1350-9047
1476-5403
DOI:10.1038/s41418-018-0155-y