Mediator: A Drawbridge across the Enhancer-Promoter Divide

Two papers in this issue of Molecular Cell provide insights into how the multisubunit Mediator coactivator complex dynamically links enhancer-bound activators to the RNA polymerase II machinery at the core promoter. Two papers in this issue of Molecular Cell provide insights into how the multisubuni...

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Bibliographic Details
Published in:Molecular cell 2016-11, Vol.64 (3), p.433-434
Main Authors: Malik, Sohail, Roeder, Robert G.
Format: Article
Language:English
Subjects:
Binding Sites
Enhancer Elements, Genetic
Gene Expression Regulation, Fungal
Mediator Complex - genetics
Mediator Complex - metabolism
Promoter Regions, Genetic
Protein Binding
Protein Subunits - genetics
Protein Subunits - metabolism
RNA Polymerase II - genetics
RNA Polymerase II - metabolism
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Transcription Factor TFIIH - genetics
Transcription Factor TFIIH - metabolism
Transcription Initiation, Genetic
Transcriptional Activation
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Summary:Two papers in this issue of Molecular Cell provide insights into how the multisubunit Mediator coactivator complex dynamically links enhancer-bound activators to the RNA polymerase II machinery at the core promoter. Two papers in this issue of Molecular Cell provide insights into how the multisubunit Mediator coactivator complex dynamically links enhancer-bound activators to the RNA polymerase II machinery at the core promoter.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2016.10.024