Mitochondrial fidelity and metabolic agility control immune cell fate and function

Remodeling of mitochondrial metabolism plays an important role in regulating immune cell fate, proliferation, and activity. Furthermore, given their bacterial ancestry, disruption in mitochondrial fidelity leading to extravasation of their content initiates and amplifies innate immune surveillance w...

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Bibliographic Details
Published in:The Journal of clinical investigation 2018-09, Vol.128 (9), p.3651-3661
Main Author: Sack, Michael N
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - immunology
Cell metabolism
Cell Polarity - immunology
Electron Transport
Genetic aspects
Health aspects
Humans
Immune response regulation
Immunity, Innate
Inflammasomes - immunology
Inflammasomes - metabolism
Medical research
Mitochondria
Mitochondria - immunology
Mitochondria - metabolism
Mitochondrial Diseases - drug therapy
Mitochondrial Diseases - immunology
Mitochondrial Diseases - metabolism
Mitochondrial Dynamics - immunology
Models, Immunological
Review Series
Signal Transduction
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Summary:Remodeling of mitochondrial metabolism plays an important role in regulating immune cell fate, proliferation, and activity. Furthermore, given their bacterial ancestry, disruption in mitochondrial fidelity leading to extravasation of their content initiates and amplifies innate immune surveillance with a myriad of physiologic and pathologic consequences. Investigations into the role of mitochondria in the immune system have come to the fore, and appreciation of mitochondrial function and quality control in immune regulation has enhanced our understanding of disease pathogenesis and identified new targets for immune modulation. This mitochondria-centered Review focuses on the role of mitochondrial metabolism and fidelity, as well as the role of the mitochondria as a structural platform, for the control of immune cell polarity, activation, and signaling. Mitochondria-linked disease and mitochondrially targeted therapeutic strategies to manage these conditions are also discussed.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI120845