Dependency relationships within the fission yeast polarity network

The ability to regulate polarised cell growth is crucial to maintain the viability of cells. Growth is modulated to facilitate essential cell functions and respond to the external environment. Failure to do so can lead to numerous developmental and disease states, including cancer. We have undertake...

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Bibliographic Details
Published in:FEBS letters 2018-08, Vol.592 (15), p.2543-2549
Main Authors: Johnson, Matthew, Mulvihill, Daniel P.
Format: Article
Language:English
Subjects:
actin
Actin Cytoskeleton - metabolism
Cell Polarity - physiology
Cell Proliferation - physiology
Cytoskeleton - metabolism
Feedback, Physiological - physiology
fission yeast
Microtubule-Associated Proteins - metabolism
microtubules
Microtubules - metabolism
Microtubules - physiology
Organisms, Genetically Modified
polarised growth
Research Letter
Research Letters
Schizosaccharomyces - cytology
Schizosaccharomyces - physiology
Schizosaccharomyces - ultrastructure
Schizosaccharomyces pombe
Schizosaccharomyces pombe Proteins - metabolism
Signal Transduction
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Summary:The ability to regulate polarised cell growth is crucial to maintain the viability of cells. Growth is modulated to facilitate essential cell functions and respond to the external environment. Failure to do so can lead to numerous developmental and disease states, including cancer. We have undertaken a detailed analysis of the regulatory interplay between molecules involved in the regulation and maintenance of polarised cell growth within fission yeast. Internally controlled live cell imaging was used to examine interactions between 10 key polarity proteins. Analysis reveals interplay between the microtubule and actin cytoskeletons, as well as multiple novel dependency pathways and feedback networks between groups of proteins. This study provides important insights into the conserved regulation of polarised cell growth within eukaryotes.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.13180