A Fully Automated Continuous‐Flow Platform for Fluorescence Quenching Studies and Stern–Volmer Analysis

Herein, we report the first fully automated continuous‐flow platform for fluorescence quenching studies and Stern–Volmer analysis. All the components of the platform were automated and controlled by a self‐written Python script. A user‐friendly software allows even inexperienced operators to perform...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-08, Vol.57 (35), p.11278-11282
Main Authors: Kuijpers, Koen P. L., Bottecchia, Cecilia, Cambié, Dario, Drummen, Koen, König, Niels J., Noël, Timothy
Format: Article
Language:English
Subjects:
Automation
Case studies
Communication
Communications
continuous flow
Fluorescence
fluorescence quenching experiments
photoredox catalysis
Programming languages
Quenching
Reproducibility
Stern–Volmer
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Summary:Herein, we report the first fully automated continuous‐flow platform for fluorescence quenching studies and Stern–Volmer analysis. All the components of the platform were automated and controlled by a self‐written Python script. A user‐friendly software allows even inexperienced operators to perform automated screening of novel quenchers or Stern–Volmer analysis, thus accelerating and facilitating both reaction discovery and mechanistic studies. The operational simplicity of our system affords a time and labor reduction over batch methods while increasing the accuracy and reproducibility of the data produced. Finally, the applicability of our platform is elucidated through relevant case studies. Rapid performance: The first fully automated continuous‐flow platform for fluorescence quenching studies and Stern–Volmer analysis is described. Equipped with user‐friendly software, the platform offers to any user the possibility to rapidly perform (
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201805632