A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide

Chitooligosaccharide (COS), which is acknowledged for possessing multiple functions, is a kind of low-molecular-weight polymer prepared by degrading chitosan via enzymatic, chemical methods, etc. COS has comprehensive applications in various fields including food, agriculture, pharmacy, clinical the...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-07, Vol.19 (8), p.2197
Main Authors: Liang, Shuang, Sun, Yaxuan, Dai, Xueling
Format: Article
Language:English
Subjects:
Acids
Adsorptivity
Agriculture
Animals
Antitumor activity
Biocompatibility
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biocompatible Materials - therapeutic use
Biodegradability
Biological activity
Cellulose acetate
Chitin
Chitin - analogs & derivatives
Chitin - chemistry
Chitin - pharmacology
Chitin - therapeutic use
Chitosan
Chitosan - chemistry
Crustaceans
Drug Delivery Systems
Food
Food Industry
Food quality
Humans
Immunomodulation
Inflammation
Low molecular weights
Methods
Mice
Models, Animal
Moisture absorption
Molecular weight
Neuroprotection
Organic chemistry
Oxidation
Peer review
Polymerization
Rats
Review
Toxicity
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Summary:Chitooligosaccharide (COS), which is acknowledged for possessing multiple functions, is a kind of low-molecular-weight polymer prepared by degrading chitosan via enzymatic, chemical methods, etc. COS has comprehensive applications in various fields including food, agriculture, pharmacy, clinical therapy, and environmental industries. Besides having excellent properties such as biodegradability, biocompatibility, adsorptive abilities and non-toxicity like chitin and chitosan, COS has better solubility. In addition, COS has strong biological functions including anti-inflammatory, antitumor, immunomodulatory, neuroprotective effects, etc. The present paper has summarized the preparation methods, analytical techniques and biological functions to provide an overall understanding of the application of COS.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19082197