The Validity and Reliability of Screening Measures for Depression and Anxiety Disorders in Inflammatory Bowel Disease

• Published in: Inflammatory bowel diseases 2018-08, Vol.24 (9), p.1867-1875
• Main Authors: Bernstein, Charles N, Zhang, Lixia, Lix, Lisa M, Graff, Lesley A, Walker, John R, Fisk, John D, Patten, Scott B, Hitchon, Carol A, Bolton, James M, Sareen, Jitender, El-Gabalawy, Renée, Marriott, James, Marrie, Ruth Ann
• Format: Article
• Language: English
• Subjects: Adult; Anxiety Disorders - diagnosis; Anxiety Disorders - etiology; Cohort Studies; Colitis, Ulcerative - psychology; Crohn Disease - psychology; Depressive Disorder - diagnosis; Depressive Disorder - etiology; Female; Humans; IBD Live; Male; Middle Aged; Patient Health Questionnaire - standards; Predictive Value of Tests; Psychiatric Status Rating Scales - standards; Psychometrics; Reproducibility of Results; ROC Curve; Sensitivity and Specificity
• ISSN: 1078-0998; 1536-4844
• DOI: 10.1093/ibd/izy068

Abstract Background We evaluated the validity and reliability of multiple symptom scales for depression and anxiety for persons with inflammatory bowel disease (IBD). Methods IBD participants in a cohort study completed a Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID) and completed the Patient Health Questionnaire (PHQ-9), Hospital Anxiety and Depression Scale (HADS), Kessler-6 Distress Scale, PROMIS Emotional Distress Depression Short-Form 8a (PROMIS Depression) and Anxiety Short-Form 8a (PROMIS Anxiety), Generalized Anxiety Disorder 7-item Scale, and Overall Anxiety and Severity Impairment Scale. We computed sensitivity, specificity, and positive and negative predictive values for the screening measures with the SCID diagnoses as the reference standard, conducted receiver operating curve (ROC) analysis, and assessed internal consistency and test-retest reliability. Results Of 242 participants, the SCID classified 8.7% as having major depression and 17.8% as having anxiety disorders. Among the depression scales, the PHQ-9 had the highest sensitivity (95%). Specificity was generally higher than sensitivity and was highest for the HADS-D (cut-point of 11; 97%). The area under the ROC curve (AUC) did not differ significantly among depression scales. Among the anxiety scales, sensitivity was highest for the PROMIS (79%). Specificity ranged from 82% to 88% for all tools except the HADS-A (cut-point of 8; 65%). The AUC did not differ between depression and anxiety tools. Conclusions Overall, the symptom scales for depression and anxiety were similar in their psychometric properties. The anxiety scales did not perform as well as the depression scales. Alternate cut-points may be more relevant when these scales are used in an IBD sample.