Mutations in gyrA and gyrB in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates

Data on the frequency of and mutations in fluoroquinolone-resistant isolates of the complex (MAC) and the complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in or in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our fin...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-09, Vol.62 (9)
Main Authors: Kim, Su-Young, Jhun, Byung Woo, Moon, Seong Mi, Shin, Sun Hye, Jeon, Kyeongman, Kwon, O Jung, Yoo, In Young, Huh, Hee Jae, Ki, Chang-Seok, Lee, Nam Yong, Shin, Sung Jae, Daley, Charles L, Suh, Gee Young, Koh, Won-Jung
Format: Article
Language:English
Subjects:
DNA Gyrase
Drug Resistance, Bacterial
Mechanisms of Resistance
Moxifloxacin
Mutation
Mycobacterium abscessus
Mycobacterium avium Complex
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Summary:Data on the frequency of and mutations in fluoroquinolone-resistant isolates of the complex (MAC) and the complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in or in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than and mutations contribute to moxifloxacin resistance in these organisms.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00527-18