Acquisition of Beta-Lactamase by Neisseria meningitidis through Possible Horizontal Gene Transfer

We report the detection in France of a beta-lactamase-producing invasive meningococcal isolate. Whole-genome sequencing of the isolate revealed a ROB-1-type beta-lactamase gene that is frequently encountered in , suggesting horizontal transfer between isolates of these bacterial species. Beta-lactam...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-09, Vol.62 (9), p.e00831-18
Main Authors: Hong, Eva, Deghmane, Ala-Eddine, Taha, Muhamed-Kheir
Format: Article
Language:English
Subjects:
Bacteriology
beta-Lactamases
Epidemiology and Surveillance
Gene Transfer, Horizontal
Haemophilus influenzae
Life Sciences
Microbiology and Parasitology
Neisseria meningitidis
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Summary:We report the detection in France of a beta-lactamase-producing invasive meningococcal isolate. Whole-genome sequencing of the isolate revealed a ROB-1-type beta-lactamase gene that is frequently encountered in , suggesting horizontal transfer between isolates of these bacterial species. Beta-lactamases are exceptional in meningococci, with no reports for more than 2 decades. This report is worrying, as the expansion of such isolates may jeopardize the effective treatment against invasive meningococcal disease.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00831-18