Functional Characterization of AbaQ, a Novel Efflux Pump Mediating Quinolone Resistance in Acinetobacter baumannii

has emerged as an important multidrug-resistant nosocomial pathogen. In previous work, we identified a putative MFS transporter, AU097_RS17040, involved in the pathogenicity of (M. Pérez-Varela, J. Corral, J. A. Vallejo, S. Rumbo-Feal, G. Bou, J. Aranda, and J. Barbé, Infect Immun 85:e00327-17, 2017...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-09, Vol.62 (9)
Main Authors: Pérez-Varela, María, Corral, Jordi, Aranda, Jesús, Barbé, Jordi
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter Infections
Anti-Bacterial Agents
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Mechanisms of Resistance
Quinolones
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Summary:has emerged as an important multidrug-resistant nosocomial pathogen. In previous work, we identified a putative MFS transporter, AU097_RS17040, involved in the pathogenicity of (M. Pérez-Varela, J. Corral, J. A. Vallejo, S. Rumbo-Feal, G. Bou, J. Aranda, and J. Barbé, Infect Immun 85:e00327-17, 2017, https://doi.org/10.1128/IAI.00327-17). In this study, we analyzed the susceptibility to diverse antimicrobial agents of cells defective in this transporter, referred to as AbaQ. Our results showed that AbaQ is mainly involved in the extrusion of quinolone-type drugs in .
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.00906-18