A TOP2A -derived cancer panel drives cancer progression in papillary renal cell carcinoma

The aim of the present study was to investigate the function of the DNA topoisomerase IIα ( gene and its associated genes in the progression of papillary renal cell carcinoma (PRCC). Online cancer databases, including cBioportal, Oncomine, OncoLnc and Search Tool for the Retrieval of Interacting Gen...

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Bibliographic Details
Published in:Oncology letters 2018-10, Vol.16 (4), p.4169-4178
Main Authors: Ye, Mushi, He, Zhuobin, Dai, Wei, Li, Zhuo, Chen, Xiaojun, Liu, Jianjun
Format: Article
Language:English
Subjects:
Analysis
Bioinformatics
Care and treatment
Deoxyribonucleic acid
Development and progression
DNA
Gene expression
Genetic aspects
Genomes
Genomics
Health aspects
Kidney cancer
Mutation
Oncology
Patients
Proteins
Renal cell carcinoma
Software
Survival analysis
Topoisomerases
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Summary:The aim of the present study was to investigate the function of the DNA topoisomerase IIα ( gene and its associated genes in the progression of papillary renal cell carcinoma (PRCC). Online cancer databases, including cBioportal, Oncomine, OncoLnc and Search Tool for the Retrieval of Interacting Genes/Proteins were used to analyze the gene expression profile, function and regulation network in PRCC. The genes that were significantly co-expressed or mutually exclusively expressed with were identified. The genes co-expressed with were defined as a ' -cancer panel', which cooperatively promotes PRCC progression. This gene panel performed well in predicting the prognosis of PRCC. In addition, the -cancer panel significantly affected the outcome of PRCC compared with clear cell renal cell carcinoma (CCRCC). The protein-protein interaction network of all genes associated with was also generated. This interaction network may provide foundation for the additional investigation of . Integrative understating of the -cancer panel may result in a novel avenue for treatment intervention in PRCC.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9179