Diagnostic value of KL-6 in idiopathic interstitial pneumonia

Idiopathic interstitial pneumonia (IIP) can induce type II alveolar epithelial cell proliferation and pulmonary basement membrane damage and subsequent release of Krebs von den Lungen-6 antigen (KL-6) to the bloodstream. This study investigated the diagnostic and prognostic value of serum KL-6 level...

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Bibliographic Details
Published in:Journal of thoracic disease 2018-08, Vol.10 (8), p.4724-4732
Main Authors: Zheng, Peiyan, Liu, Xiaoqing, Huang, Huimin, Guo, Zijun, Wu, Ge, Hu, Haisheng, Cai, Chuanxu, Luo, Wenting, Wei, Nili, Han, Qian, Sun, Baoqing
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Language:English
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Summary:Idiopathic interstitial pneumonia (IIP) can induce type II alveolar epithelial cell proliferation and pulmonary basement membrane damage and subsequent release of Krebs von den Lungen-6 antigen (KL-6) to the bloodstream. This study investigated the diagnostic and prognostic value of serum KL-6 levels for IIP. One hundred five patients with lung disease were divided into IIP (n=75) and non-IIP groups (n=30) according to pathological and computed tomography findings. Serum KL-6 levels were evaluated in blood samples from all subjects. Nineteen IIP group patients were also subjected to a longitudinal study of disease progression and serum KL-6 levels over time. Serum KL-6 levels were significantly higher in the IIP group the non-IIP group [1,096.0 (565.0-1,544.0) 226.0 (173.5-346.5) U/mL; P
ISSN:2072-1439
2077-6624
DOI:10.21037/jtd.2018.07.54