Loading…
Engineering rice with lower grain arsenic
Summary Arsenic (As) is a poisonous element that causes severe skin lesions and cancer in humans. Rice (Oryza sativa L.) is a major dietary source of As in humans who consume this cereal as a staple food. We hypothesized that increasing As vacuolar sequestration would inhibit its translocation into...
Saved in:
| Published in: | Plant biotechnology journal 2018-10, Vol.16 (10), p.1691-1699 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4825-6d418387a9770fc3c0dba41655ab39e9b3d08558ab782d074835e1e91897a1523 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4825-6d418387a9770fc3c0dba41655ab39e9b3d08558ab782d074835e1e91897a1523 |
| container_end_page | 1699 |
| container_issue | 10 |
| container_start_page | 1691 |
| container_title | Plant biotechnology journal |
| container_volume | 16 |
| creator | Deng, Fenglin Yamaji, Naoki Ma, Jian Feng Lee, Sang‐Kyu Jeon, Jong‐Seong Martinoia, Enrico Lee, Youngsook Song, Won‐Yong |
| description | Summary
Arsenic (As) is a poisonous element that causes severe skin lesions and cancer in humans. Rice (Oryza sativa L.) is a major dietary source of As in humans who consume this cereal as a staple food. We hypothesized that increasing As vacuolar sequestration would inhibit its translocation into the grain and reduce the amount of As entering the food chain. We developed transgenic rice plants expressing two different vacuolar As sequestration genes, ScYCF1 and OsABCC1, under the control of the RCc3 promoter in the root cortical and internode phloem cells, along with a bacterial γ‐glutamylcysteine synthetase driven by the maize UBI promoter. The transgenic rice plants exhibited reduced root‐to‐shoot and internode‐to‐grain As translocation, resulting in a 70% reduction in As accumulation in the brown rice without jeopardizing agronomic traits. This technology could be used to reduce As intake, particularly in populations of South East Asia suffering from As toxicity and thereby improve human health. |
| doi_str_mv | 10.1111/pbi.12905 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6131421</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A733243732</galeid><sourcerecordid>A733243732</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4825-6d418387a9770fc3c0dba41655ab39e9b3d08558ab782d074835e1e91897a1523</originalsourceid><addsrcrecordid>eNp1kUtPAjEUhRujEXws_ANmElcsBvqcthsTJKgkJLrQddPpdIYS6GAHJPx7i4NEF7aLNu3pd0_vAeAGwT6KY7DKXR9hCdkJ6CKa8ZRnDJ8e95R2wEXTzCHEKGPZOehgSbnkAnZBb-wr560NzldJcMYmW7eeJYt6a0NSBe18okNjvTNX4KzUi8ZeH9ZL8P44fhs9p9OXp8loOE0NFZilWUGRIIJryTksDTGwyDWNdZnOibQyJwUUjAmdc4ELyKkgzCIrkZBcI4bJJbhvuatNvrSFsX4d9EKtglvqsFO1durvjXczVdWfKkMEUYwi4O4ACPXHxjZrNa83wUfPCiOIBN63Kqr6rarSC6ucL-sIM3EWdulM7W3p4vmQE4Ip4WTvq9c-MKFummDLoyUE1T4GFWNQ3zFE7e3vPxyVP32PgkEr2MYqu_9J6vVh0iK_AMB2j2w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2101821290</pqid></control><display><type>article</type><title>Engineering rice with lower grain arsenic</title><source>Wiley-Blackwell Open Access Collection</source><source>Publicly Available Content Database</source><creator>Deng, Fenglin ; Yamaji, Naoki ; Ma, Jian Feng ; Lee, Sang‐Kyu ; Jeon, Jong‐Seong ; Martinoia, Enrico ; Lee, Youngsook ; Song, Won‐Yong</creator><creatorcontrib>Deng, Fenglin ; Yamaji, Naoki ; Ma, Jian Feng ; Lee, Sang‐Kyu ; Jeon, Jong‐Seong ; Martinoia, Enrico ; Lee, Youngsook ; Song, Won‐Yong</creatorcontrib><description>Summary
Arsenic (As) is a poisonous element that causes severe skin lesions and cancer in humans. Rice (Oryza sativa L.) is a major dietary source of As in humans who consume this cereal as a staple food. We hypothesized that increasing As vacuolar sequestration would inhibit its translocation into the grain and reduce the amount of As entering the food chain. We developed transgenic rice plants expressing two different vacuolar As sequestration genes, ScYCF1 and OsABCC1, under the control of the RCc3 promoter in the root cortical and internode phloem cells, along with a bacterial γ‐glutamylcysteine synthetase driven by the maize UBI promoter. The transgenic rice plants exhibited reduced root‐to‐shoot and internode‐to‐grain As translocation, resulting in a 70% reduction in As accumulation in the brown rice without jeopardizing agronomic traits. This technology could be used to reduce As intake, particularly in populations of South East Asia suffering from As toxicity and thereby improve human health.</description><identifier>ISSN: 1467-7644</identifier><identifier>EISSN: 1467-7652</identifier><identifier>DOI: 10.1111/pbi.12905</identifier><identifier>PMID: 29479780</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>ABC transporter ; Agronomy ; Arsenic ; Biotechnology ; Cancer ; Food ; Food chains ; Genetic engineering ; Genetically engineered foods ; Grain ; Lesions ; Oryza sativa ; Plants ; Rice ; Skin diseases ; Toxicity ; Transgenic plants ; Translocation ; vacuolar sequestration ; γ-Glutamylcysteine</subject><ispartof>Plant biotechnology journal, 2018-10, Vol.16 (10), p.1691-1699</ispartof><rights>2018 The Authors. published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.</rights><rights>2018 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4825-6d418387a9770fc3c0dba41655ab39e9b3d08558ab782d074835e1e91897a1523</citedby><cites>FETCH-LOGICAL-c4825-6d418387a9770fc3c0dba41655ab39e9b3d08558ab782d074835e1e91897a1523</cites><orcidid>0000-0002-9872-5071 ; 0000-0003-3411-827X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2101821290/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2101821290?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,11562,25753,27924,27925,37012,44590,46052,46476,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29479780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Fenglin</creatorcontrib><creatorcontrib>Yamaji, Naoki</creatorcontrib><creatorcontrib>Ma, Jian Feng</creatorcontrib><creatorcontrib>Lee, Sang‐Kyu</creatorcontrib><creatorcontrib>Jeon, Jong‐Seong</creatorcontrib><creatorcontrib>Martinoia, Enrico</creatorcontrib><creatorcontrib>Lee, Youngsook</creatorcontrib><creatorcontrib>Song, Won‐Yong</creatorcontrib><title>Engineering rice with lower grain arsenic</title><title>Plant biotechnology journal</title><addtitle>Plant Biotechnol J</addtitle><description>Summary
Arsenic (As) is a poisonous element that causes severe skin lesions and cancer in humans. Rice (Oryza sativa L.) is a major dietary source of As in humans who consume this cereal as a staple food. We hypothesized that increasing As vacuolar sequestration would inhibit its translocation into the grain and reduce the amount of As entering the food chain. We developed transgenic rice plants expressing two different vacuolar As sequestration genes, ScYCF1 and OsABCC1, under the control of the RCc3 promoter in the root cortical and internode phloem cells, along with a bacterial γ‐glutamylcysteine synthetase driven by the maize UBI promoter. The transgenic rice plants exhibited reduced root‐to‐shoot and internode‐to‐grain As translocation, resulting in a 70% reduction in As accumulation in the brown rice without jeopardizing agronomic traits. This technology could be used to reduce As intake, particularly in populations of South East Asia suffering from As toxicity and thereby improve human health.</description><subject>ABC transporter</subject><subject>Agronomy</subject><subject>Arsenic</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Food</subject><subject>Food chains</subject><subject>Genetic engineering</subject><subject>Genetically engineered foods</subject><subject>Grain</subject><subject>Lesions</subject><subject>Oryza sativa</subject><subject>Plants</subject><subject>Rice</subject><subject>Skin diseases</subject><subject>Toxicity</subject><subject>Transgenic plants</subject><subject>Translocation</subject><subject>vacuolar sequestration</subject><subject>γ-Glutamylcysteine</subject><issn>1467-7644</issn><issn>1467-7652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><recordid>eNp1kUtPAjEUhRujEXws_ANmElcsBvqcthsTJKgkJLrQddPpdIYS6GAHJPx7i4NEF7aLNu3pd0_vAeAGwT6KY7DKXR9hCdkJ6CKa8ZRnDJ8e95R2wEXTzCHEKGPZOehgSbnkAnZBb-wr560NzldJcMYmW7eeJYt6a0NSBe18okNjvTNX4KzUi8ZeH9ZL8P44fhs9p9OXp8loOE0NFZilWUGRIIJryTksDTGwyDWNdZnOibQyJwUUjAmdc4ELyKkgzCIrkZBcI4bJJbhvuatNvrSFsX4d9EKtglvqsFO1durvjXczVdWfKkMEUYwi4O4ACPXHxjZrNa83wUfPCiOIBN63Kqr6rarSC6ucL-sIM3EWdulM7W3p4vmQE4Ip4WTvq9c-MKFummDLoyUE1T4GFWNQ3zFE7e3vPxyVP32PgkEr2MYqu_9J6vVh0iK_AMB2j2w</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Deng, Fenglin</creator><creator>Yamaji, Naoki</creator><creator>Ma, Jian Feng</creator><creator>Lee, Sang‐Kyu</creator><creator>Jeon, Jong‐Seong</creator><creator>Martinoia, Enrico</creator><creator>Lee, Youngsook</creator><creator>Song, Won‐Yong</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>LK8</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9872-5071</orcidid><orcidid>https://orcid.org/0000-0003-3411-827X</orcidid></search><sort><creationdate>201810</creationdate><title>Engineering rice with lower grain arsenic</title><author>Deng, Fenglin ; Yamaji, Naoki ; Ma, Jian Feng ; Lee, Sang‐Kyu ; Jeon, Jong‐Seong ; Martinoia, Enrico ; Lee, Youngsook ; Song, Won‐Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4825-6d418387a9770fc3c0dba41655ab39e9b3d08558ab782d074835e1e91897a1523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>ABC transporter</topic><topic>Agronomy</topic><topic>Arsenic</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Food</topic><topic>Food chains</topic><topic>Genetic engineering</topic><topic>Genetically engineered foods</topic><topic>Grain</topic><topic>Lesions</topic><topic>Oryza sativa</topic><topic>Plants</topic><topic>Rice</topic><topic>Skin diseases</topic><topic>Toxicity</topic><topic>Transgenic plants</topic><topic>Translocation</topic><topic>vacuolar sequestration</topic><topic>γ-Glutamylcysteine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Fenglin</creatorcontrib><creatorcontrib>Yamaji, Naoki</creatorcontrib><creatorcontrib>Ma, Jian Feng</creatorcontrib><creatorcontrib>Lee, Sang‐Kyu</creatorcontrib><creatorcontrib>Jeon, Jong‐Seong</creatorcontrib><creatorcontrib>Martinoia, Enrico</creatorcontrib><creatorcontrib>Lee, Youngsook</creatorcontrib><creatorcontrib>Song, Won‐Yong</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Plant biotechnology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Fenglin</au><au>Yamaji, Naoki</au><au>Ma, Jian Feng</au><au>Lee, Sang‐Kyu</au><au>Jeon, Jong‐Seong</au><au>Martinoia, Enrico</au><au>Lee, Youngsook</au><au>Song, Won‐Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering rice with lower grain arsenic</atitle><jtitle>Plant biotechnology journal</jtitle><addtitle>Plant Biotechnol J</addtitle><date>2018-10</date><risdate>2018</risdate><volume>16</volume><issue>10</issue><spage>1691</spage><epage>1699</epage><pages>1691-1699</pages><issn>1467-7644</issn><eissn>1467-7652</eissn><abstract>Summary
Arsenic (As) is a poisonous element that causes severe skin lesions and cancer in humans. Rice (Oryza sativa L.) is a major dietary source of As in humans who consume this cereal as a staple food. We hypothesized that increasing As vacuolar sequestration would inhibit its translocation into the grain and reduce the amount of As entering the food chain. We developed transgenic rice plants expressing two different vacuolar As sequestration genes, ScYCF1 and OsABCC1, under the control of the RCc3 promoter in the root cortical and internode phloem cells, along with a bacterial γ‐glutamylcysteine synthetase driven by the maize UBI promoter. The transgenic rice plants exhibited reduced root‐to‐shoot and internode‐to‐grain As translocation, resulting in a 70% reduction in As accumulation in the brown rice without jeopardizing agronomic traits. This technology could be used to reduce As intake, particularly in populations of South East Asia suffering from As toxicity and thereby improve human health.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>29479780</pmid><doi>10.1111/pbi.12905</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9872-5071</orcidid><orcidid>https://orcid.org/0000-0003-3411-827X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1467-7644 |
| ispartof | Plant biotechnology journal, 2018-10, Vol.16 (10), p.1691-1699 |
| issn | 1467-7644 1467-7652 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6131421 |
| source | Wiley-Blackwell Open Access Collection; Publicly Available Content Database |
| subjects | ABC transporter Agronomy Arsenic Biotechnology Cancer Food Food chains Genetic engineering Genetically engineered foods Grain Lesions Oryza sativa Plants Rice Skin diseases Toxicity Transgenic plants Translocation vacuolar sequestration γ-Glutamylcysteine |
| title | Engineering rice with lower grain arsenic |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A56%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Engineering%20rice%20with%20lower%20grain%20arsenic&rft.jtitle=Plant%20biotechnology%20journal&rft.au=Deng,%20Fenglin&rft.date=2018-10&rft.volume=16&rft.issue=10&rft.spage=1691&rft.epage=1699&rft.pages=1691-1699&rft.issn=1467-7644&rft.eissn=1467-7652&rft_id=info:doi/10.1111/pbi.12905&rft_dat=%3Cgale_pubme%3EA733243732%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4825-6d418387a9770fc3c0dba41655ab39e9b3d08558ab782d074835e1e91897a1523%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2101821290&rft_id=info:pmid/29479780&rft_galeid=A733243732&rfr_iscdi=true |