Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and neurodegeneration in the hippocampus. Despite the pathological importance of the hippocampal degeneration in AD, little topographical evidence exists of impaired hippocampal connectivity in patients with...

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Bibliographic Details
Published in:Molecular neurobiology 2018-10, Vol.55 (10), p.7886-7899
Main Authors: Jeon, Seong Gak, Kim, Yong Jun, Kim, Kyoung Ah, Mook-Jung, Inhee, Moon, Minho
Format: Article
Language:English
Subjects:
Alzheimer Disease - pathology
Alzheimer's disease
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cognitive ability
Cortex (entorhinal)
Disease Models, Animal
Entorhinal Cortex - pathology
Hippocampus
Hippocampus - pathology
Humans
Locus coeruleus
Locus Coeruleus - pathology
Mice
Mice, Transgenic
Nerve Net - pathology
Neural networks
Neurobiology
Neurodegeneration
Neurodegenerative diseases
Neurology
Neurons - pathology
Neurosciences
Olfactory bulb
Olfactory Bulb - pathology
Olfactory stimuli
Perchlorate
Perchloric acid
Raphe Nuclei - pathology
Reproducibility of Results
Rodents
Septum
Substantia nigra
Substantia Nigra - pathology
Visualization
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Description
Summary:Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and neurodegeneration in the hippocampus. Despite the pathological importance of the hippocampal degeneration in AD, little topographical evidence exists of impaired hippocampal connectivity in patients with AD. To investigate the anatomical connections of the hippocampus, we injected the neurotracer 1,1′-dioctadecyl-3,3,3′3,3′-tetramethyl-indocarbocyanine perchlorate (DiI) into the hippocampi of 5XFAD mice, which were used as an animal model of AD. In wild-type controls, DiI-containing cells were found in the entorhinal cortex, medial septum, locus coeruleus, dorsal raphe, substantia nigra pars compacta, and olfactory bulb. Hippocampal inputs were decreased in multiple brain regions in the 5XFAD mice compared to wild-type littermate mice. These results are the first to reveal alterations at the cellular level in hippocampal connectivity in the brains of 5XFAD mice. These results suggest that anatomical mapping of hippocampal connectivity will elucidate new pathogenic mechanisms and therapeutic targets for AD treatment.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-018-0918-y