Nicotinic Acetylcholine Receptors in HIV: Possible Roles During HAND and Inflammation

Infection with the human immunodeficiency virus (HIV) remains a threat to global health. Since its discovery, many efforts have been directed at understanding the mechanisms and consequences of infection. Although there have been substantial advances since the advent of antiretroviral therapy, there...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2018-10, Vol.38 (7), p.1335-1348
Main Authors: Capó-Vélez, Coral M., Delgado-Vélez, Manuel, Báez-Pagán, Carlos A., Lasalde-Dominicci, José A.
Format: Article
Language:English
Subjects:
Acetylcholine receptors (nicotinic)
Antiretroviral therapy
Biomedical and Life Sciences
Biomedicine
Cell Biology
Central nervous system
Cognition
HIV
Human immunodeficiency virus
Inflammation
Neurobiology
Neurosciences
Review Paper
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Summary:Infection with the human immunodeficiency virus (HIV) remains a threat to global health. Since its discovery, many efforts have been directed at understanding the mechanisms and consequences of infection. Although there have been substantial advances since the advent of antiretroviral therapy, there are still complications that significantly compromise the health of infected patients, particularly, chronic inflammation and HIV-associated neurocognitive disorders (HAND). In this review, a new perspective is addressed in the field of HIV, where the alpha7 nicotinic acetylcholine receptor (α7-nAChR) is the protagonist. We comprehensively discuss the available evidence implicating α7-nAChRs in the context of HIV and provide possible explanations about its role in HAND and inflammation in both the central nervous system and the periphery.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-018-0603-8