The Limits and Potential Future Applications of Personalized Medicine to Prevent Complex Chronic Disease

The milestone sequencing of the human genome more than a decade ago dawned a genomic revolution with the potential of transforming health. The anticipated benefits included the identification of the early biomarkers of disease, the ability to combine information on risk-conferring genes to improve r...

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Bibliographic Details
Published in:Public health reports (1974) 2018-09, Vol.133 (5), p.519-522
Main Authors: Bergquist, Sharon Horesh, Lobelo, Felipe
Format: Article
Language:English
Subjects:
Biomarkers - analysis
Chronic Disease - prevention & control
Chronic illnesses
Commentary
Disease
Genetic Predisposition to Disease
Health care policy
Health services
Humans
Medicine
Patients
Phenotype
Precision Medicine
Primary Prevention
Public health
Risk Assessment
Risk Reduction Behavior
Secondary Prevention
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Summary:The milestone sequencing of the human genome more than a decade ago dawned a genomic revolution with the potential of transforming health. The anticipated benefits included the identification of the early biomarkers of disease, the ability to combine information on risk-conferring genes to improve risk prediction, and the discovery of new disease pathways that can serve as the target for novel therapeutics. Despite monumental breakthroughs, however, genomic science is in its infancy. A gap remains between science and patient benefit. A growing concern is that for the term "personalized medicine" has become a proxy for DNA-centered approaches to prevention and treatment.
ISSN:0033-3549
1468-2877
DOI:10.1177/0033354918781568