Staphylococcus aureus in the nose and throat of Iowan families

The study objective was to determine the prevalence of Staphylococcus aureus colonisation in the nares and oropharynx of healthy persons and identify any risk factors associated with such S. aureus colonisation. In total 263 participants (177 adults and 86 minors) comprising 95 families were enrolle...

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Bibliographic Details
Published in:Epidemiology and infection 2018-10, Vol.146 (14), p.1777-1784
Main Authors: Hanson, B M, Kates, A E, O'Malley, S M, Mills, E, Herwaldt, L A, Torner, J C, Dawson, J D, Farina, S A, Klostermann, C, Wu, J Y, Quick, M K, Forshey, B M, Smith, T C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Carrier State - epidemiology
Carrier State - microbiology
Child
Child, Preschool
Female
Humans
Infant
Iowa - epidemiology
Male
Middle Aged
Nose - microbiology
Oropharynx - microbiology
Prevalence
Prospective Studies
Risk Factors
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcus aureus - isolation & purification
Young Adult
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Summary:The study objective was to determine the prevalence of Staphylococcus aureus colonisation in the nares and oropharynx of healthy persons and identify any risk factors associated with such S. aureus colonisation. In total 263 participants (177 adults and 86 minors) comprising 95 families were enrolled in a year-long prospective cohort study from one urban and one rural county in eastern Iowa, USA, through local newspaper advertisements and email lists and through the Keokuk Rural Health Study. Potential risk factors including demographic factors, medical history, farming and healthcare exposure were assessed. Among the participants, 25.4% of adults and 36.1% minors carried S. aureus in their nares and 37.9% of adults carried it in their oropharynx. The overall prevalence was 44.1% among adults and 36.1% for minors. Having at least one positive environmental site for S. aureus in the family home was associated with colonisation (prevalence ratio: 1.34, 95% CI: 1.07-1.66). The sensitivity of the oropharyngeal cultures was greater than that of the nares cultures (86.1% compared with 58.2%, respectively). In conclusion, the nares and oropharynx are both important colonisation sites for healthy community members and the presence of S. aureus in the home environment is associated with an increased probability of colonisation.
ISSN:0950-2688
1469-4409
1469-4409
DOI:10.1017/S0950268818001644