Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

Manganese superoxide dismutase (MnSOD) plays a critical role in the defense against reactive oxygen species. The association between MnSOD Val16Ala polymorphism and cancer risk has been widely studied, but the results are contradictory. To obtain more precision on the association, we performed the c...

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Bibliographic Details
Published in:Disease markers 2018-01, Vol.2018 (2018), p.1-16
Main Authors: Li, Sanqiang, Xi, Shoumin, Zhu, Yanfeng, Wang, Ping, Zhang, Yanle
Format: Article
Language:English
Subjects:
Asian People
Cancer
Case-Control Studies
Confidence intervals
Female
Genetic aspects
Genetic Predisposition to Disease
Health aspects
Humans
Male
Manganese
Medical care
Neoplasms - genetics
Oncology, Experimental
Polymorphism
Polymorphism, Genetic
Population studies
Prostate
Prostate cancer
Quality management
Review
Risk
Risk factors
Statistical analysis
Superoxide
Superoxide dismutase
Superoxide Dismutase - genetics
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Summary:Manganese superoxide dismutase (MnSOD) plays a critical role in the defense against reactive oxygen species. The association between MnSOD Val16Ala polymorphism and cancer risk has been widely studied, but the results are contradictory. To obtain more precision on the association, we performed the current meta-analysis with 33,098 cases and 37,831 controls from 88 studies retrieved from PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association. We found that the polymorphism was associated with an increased overall cancer risk (homozygous: OR=1.09, 95% CI = 1.00–1.19; heterozygous: OR=1.07, 95% CI = 1.02–1.12; dominant: OR=1.08, 95% CI = 1.02–1.14; and allele comparison: OR=1.06, 95% CI = 1.02–1.11). Stratification analysis further showed an increased risk for prostate cancer, Asians, Caucasians, population-based studies, hospital-based studies, low quality and high quality studies. However, the increased risk for MnSOD Val16Ala polymorphism among Asians needs further validation based on the false-positive report probability (FPRP) test. To summarize, this meta-analysis suggests that the MnSOD Val16Ala polymorphism is associated with significantly increased cancer risk, which needs further validation in single large studies.
ISSN:0278-0240
1875-8630
DOI:10.1155/2018/3061974