Multiplexed microarrays based on optically encoded microbeads

In recent years, there has been growing interest in optically-encoded or tagged functionalized microbeads as a solid support platform to capture proteins or nucleotides which may serve as biomarkers of various diseases. Multiplexing technologies (suspension array or planar array) based on optically...

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Bibliographic Details
Published in:Biomedical microdevices 2018-08, Vol.20 (3), p.66-14, Article 66
Main Authors: Vafajoo, Atieh, Rostami, Azin, Foroutan Parsa, Sanam, Salarian, Reza, Rabiee, Navid, Rabiee, Ghazal, Rabiee, Mohammad, Tahriri, Mohammadreza, Vashaee, Daryoosh, Tayebi, Lobat, Hamblin, Michael R.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biomarkers
Biomedical Engineering and Bioengineering
Biophysics
Cancer
Cell Line, Tumor
Coding
Computer Simulation
Diagnostic systems
Diseases
Engineering
Engineering Fluid Dynamics
Flow Cytometry
Fluorescent Dyes
Humans
Medical diagnosis
Microarray Analysis
Microspheres
Multiplexing
Nanoparticles
Nanoparticles - chemistry
Nanotechnology
Neoplasms - diagnosis
Nucleotides
Optical Phenomena
Polymerization
Proteins
Proteins - chemistry
Surface Properties
Technology
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Summary:In recent years, there has been growing interest in optically-encoded or tagged functionalized microbeads as a solid support platform to capture proteins or nucleotides which may serve as biomarkers of various diseases. Multiplexing technologies (suspension array or planar array) based on optically encoded microspheres have made possible the observation of relatively minor changes in biomarkers related to specific diseases. The ability to identify these changes at an early stage may allow the diagnosis of serious diseases (e.g. cancer) at a time-point when curative treatment may still be possible. As the overall accuracy of current diagnostic methods for some diseases is often disappointing, multiplexed assays based on optically encoded microbeads could play an important role to detect biomarkers of diseases in a non-invasive and accurate manner. However, detection systems based on functionalized encoded microbeads are still an emerging technology, and more research needs to be done in the future. This review paper is a preliminary attempt to summarize the state-of-the-art concerning diagnostic microbeads; including microsphere composition, synthesis, encoding technology, detection systems, and applications.
ISSN:1387-2176
1572-8781
DOI:10.1007/s10544-018-0314-4