Diagnostic value of platelet-derived microparticles in pulmonary thromboembolism: A population-based study

• Published in: Experimental and therapeutic medicine 2018-10, Vol.16 (4), p.3099-3106
• Main Authors: Wang, Minglian, Fu, Yingyun, Xu, Lan, Xiao, Lu, Yue, Yongjian, Liu, Shengguo, Huang, Qijun, Li, Shulin, Li, Yazhen
• Format: Article
• Language: English
• Subjects: Anticoagulants; Biomarkers; Blood platelets; Cardiovascular disease; Chronic obstructive pulmonary disease; Clinical medicine; Diagnosis; Fibrinolytic agents; Health aspects; Health risk assessment; Hypertension; Medical diagnosis; Population-based studies; Pregnant women; Proteins; Pulmonary arteries; Pulmonary embolism; Risk factors; Thromboembolism; Thrombosis
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2018.6579

An early and accurate diagnosis of pulmonary thromboembolism (PTE) remains challenging. The present study aimed to evaluate the diagnostic value of platelet-derived microparticles in PTE based on a population study. A total of 102 patients with PTE, 102 healthy controls and 40 patients suspected with PTE were enrolled in this study. The platelet count, mean platelet volume and platelet distribution width were assessed using an automated hematology analyzer, P-selectin was assessed using an ELISA kit and PMPs were explored using flow cytometry using Megamix beads. Receiver operating characteristic curves were established to evaluate the diagnostic values of PMPs, D-dimer, PMPs combined with D-dimer, and multiple parameters (including PMPs, platelet distribution width, P-selectin and D-dimer in PTE). The PMP levels were significantly higher in the patients with PTE (609.10/µl) compared with those in the healthy controls (230.60/µl) and patients with suspicious PTE (166.70/µl; P0.05). The combination of D-dimer and PMPs significantly increased the sensitivity (86.27%) of D-dimer and the specificity of PMP for the diagnosis of PTE (P