Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines

Recent studies have indicated the significance of immune checkpoint molecules including programmed death-1 (PD-1), cytotoxic T-lymphocyte associated protein 4, and T-cell immunoglobulin and mucin domain-containing molecule-3 for anti-tumor immune responses. We previously investigated PD-1 ligand 1/2...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Clinical and Experimental Hematopathology 2017, Vol.57(1), pp.21-25
Main Authors: Ma, Chaoya, Horlad, Hasita, Pan, Cheng, Yano, Hiromu, Ohnishi, Koji, Fujiwara, Yukio, Matsuoka, Masao, Lee, Aeju, Niidome, Takuro, Yamanaka, Ryuya, Takeya, Motohiro, Komohara, Yoshihiro
Format: Article
Language:English
Subjects:
lymphoma
Original
PD-L1
PD-L2
Stat3
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent studies have indicated the significance of immune checkpoint molecules including programmed death-1 (PD-1), cytotoxic T-lymphocyte associated protein 4, and T-cell immunoglobulin and mucin domain-containing molecule-3 for anti-tumor immune responses. We previously investigated PD-1 ligand 1/2 (PD-L1/2) expression in lymphoma cell lines, and found that PD-L1/2 is expressed on the adult T-cell leukemia/lymphoma (ATL-T) and B-cell lymphoma (SLVL) cell lines. In the present study, we investigated whether the Stat3 inhibitor WP1066 abrogated PD-L1/2 expression in lymphoma cell lines. Incubation with WP1066 inhibited lymphoma cell growth and induced cell apoptosis. PD-L1/2 expression in the ATL-T, SLVL, and human brain malignant lymphoma (HKBML) cell lines was significantly abrogated by WP1066 treatment. These data indicated that a Stat3 inhibitor abrogated PD-L1/2 expression in lymphoma cells. Such an inhibitor is therefore considered to be useful for additional immunotherapy in patients with advanced lymphoma.
ISSN:1346-4280
1880-9952
DOI:10.3960/jslrt.17006