Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency

We report a case of acute massive pulmonary embolism in a patient with antithrombin III deficiency. The patient was treated with rivaroxaban. The patient responded well to the therapy, and contrast-enhanced computed tomography showed nearly complete disappearance of the pulmonary embolism. Patients...

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Bibliographic Details
Published in:Journal of cardiology cases 2017-11, Vol.16 (5), p.144-147
Main Authors: Yamaguchi, Junji, Hara, Nobuhiro, Yamaguchi, Tetsuo, Nagata, Yasutoshi, Nozato, Toshihiro, Miyamoto, Takamichi
Format: Article
Language:English
Subjects:
Antithrombin-III deficiency
Direct oral anticoagulants
Venous thromboembolism
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Summary:We report a case of acute massive pulmonary embolism in a patient with antithrombin III deficiency. The patient was treated with rivaroxaban. The patient responded well to the therapy, and contrast-enhanced computed tomography showed nearly complete disappearance of the pulmonary embolism. Patients with low antithrombin III activity may have resistance to heparin therapy, leading to insufficient anticoagulation during the acute phase of thromboembolism. This case suggests that direct oral anticoagulants, such as rivaroxaban, may be effective first-line agents for treating venous thromboembolism in patients with antithrombin III deficiency.
ISSN:1878-5409
1878-5409
DOI:10.1016/j.jccase.2017.06.008