Cell culture-derived flu vaccine: Present and future

The benefit of influenza vaccines is difficult to estimate due to the complexity of accurately assessing the burden of influenza. To improve the efficacy of influenza vaccines, vaccine manufacturers have developed quadrivalent influenza vaccine (QIV) formulations for seasonal vaccination by includin...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2018-01, Vol.14 (8), p.1874-1882
Main Authors: Pérez Rubio, Alberto, Eiros, Jose María
Format: Article
Language:English
Subjects:
Animals
cell culture derived
Cell Culture Techniques - methods
Chick Embryo
egg production
Humans
influenza
Influenza A virus - immunology
Influenza B virus - immunology
Influenza Vaccines - immunology
Influenza Vaccines - isolation & purification
Influenza, Human - immunology
Influenza, Human - prevention & control
Influenza, Human - virology
quadriavalent
Review
Technology, Pharmaceutical - methods
vaccine
vaccinology
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Summary:The benefit of influenza vaccines is difficult to estimate due to the complexity of accurately assessing the burden of influenza. To improve the efficacy of influenza vaccines, vaccine manufacturers have developed quadrivalent influenza vaccine (QIV) formulations for seasonal vaccination by including both influenza B lineages. Three parallel approaches for producing influenza vaccines are attracting the interest of many vaccine manufacturing companies. The first and oldest is the conventional egg-derived influenza vaccine, which is used by the current licensed influenza vaccines. The second approach is a cell culture-derived influenza vaccine, and the third and most recent is synthetic vaccines. Here, we analyze the difficulties with vaccines production in eggs and compare this to cell culture-derived influenza vaccines and discuss the future of cell culture-derived QIVs.Keywords: Influenza vaccine, cell culture-derived, quadrivalent.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2018.1460297