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Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides
Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. has been known for its anti-inflammatory and antidiarrheal properties in Mexican t...
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Published in: | Molecules (Basel, Switzerland) Switzerland), 2017-05, Vol.22 (5), p.799 |
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creator | Gutiérrez-Gutiérrez, Filiberto Puebla-Pérez, Ana María González-Pozos, Sirenia Hernández-Hernández, José Manuel Pérez-Rangel, Armando Alvarez, Laura Patricia Tapia-Pastrana, Gabriela Castillo-Romero, Araceli |
description | Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects.
has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from
var.
, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the
adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity and low toxicity on Caco-2 cells. This finding makes it an attractive potential starting point for new antigiardial drugs. |
doi_str_mv | 10.3390/molecules22050799 |
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has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from
var.
, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the
adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity and low toxicity on Caco-2 cells. This finding makes it an attractive potential starting point for new antigiardial drugs.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules22050799</identifier><identifier>PMID: 28505094</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adhesion ; Antiprotozoal Agents - chemistry ; Antiprotozoal Agents - pharmacology ; Antiviral drugs ; Bursera - chemistry ; Caco-2 Cells ; Cell growth ; Cell Survival - drug effects ; Developing countries ; Diarrhea ; Drug dosages ; Drugs ; Electron microscopy ; Epithelium ; Flagella ; Giardiasis ; Humans ; In vitro methods and tests ; Inflammation ; Inhibition ; Intestine ; LDCs ; Lignans ; Microscopy ; Morphology ; Parasites ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Podophyllotoxin ; Podophyllotoxin - chemistry ; Podophyllotoxin - pharmacology ; Protozoa ; Side effects ; Toxicity</subject><ispartof>Molecules (Basel, Switzerland), 2017-05, Vol.22 (5), p.799</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-eb68c4c4701e1fd6b14e453985d7bc35d2fc900054452ed58fa07bd0944f62083</citedby><cites>FETCH-LOGICAL-c427t-eb68c4c4701e1fd6b14e453985d7bc35d2fc900054452ed58fa07bd0944f62083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1910594430/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1910594430?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28505094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gutiérrez-Gutiérrez, Filiberto</creatorcontrib><creatorcontrib>Puebla-Pérez, Ana María</creatorcontrib><creatorcontrib>González-Pozos, Sirenia</creatorcontrib><creatorcontrib>Hernández-Hernández, José Manuel</creatorcontrib><creatorcontrib>Pérez-Rangel, Armando</creatorcontrib><creatorcontrib>Alvarez, Laura Patricia</creatorcontrib><creatorcontrib>Tapia-Pastrana, Gabriela</creatorcontrib><creatorcontrib>Castillo-Romero, Araceli</creatorcontrib><title>Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects.
has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from
var.
, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the
adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity and low toxicity on Caco-2 cells. This finding makes it an attractive potential starting point for new antigiardial drugs.</description><subject>Adhesion</subject><subject>Antiprotozoal Agents - chemistry</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Antiviral drugs</subject><subject>Bursera - chemistry</subject><subject>Caco-2 Cells</subject><subject>Cell growth</subject><subject>Cell Survival - drug effects</subject><subject>Developing countries</subject><subject>Diarrhea</subject><subject>Drug dosages</subject><subject>Drugs</subject><subject>Electron microscopy</subject><subject>Epithelium</subject><subject>Flagella</subject><subject>Giardiasis</subject><subject>Humans</subject><subject>In vitro methods and tests</subject><subject>Inflammation</subject><subject>Inhibition</subject><subject>Intestine</subject><subject>LDCs</subject><subject>Lignans</subject><subject>Microscopy</subject><subject>Morphology</subject><subject>Parasites</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Podophyllotoxin</subject><subject>Podophyllotoxin - chemistry</subject><subject>Podophyllotoxin - pharmacology</subject><subject>Protozoa</subject><subject>Side effects</subject><subject>Toxicity</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNplUU1PGzEUtFBRgbQ_gEu1Ui-9LDx_ZdcXpID4qBQJDnCsLK8_EiPvOti7UfPvWUSI0nJ67-nNjGY0CJ1iOKNUwHkbg9VDsJkQ4FAJcYCOMSNQUmDiy95-hE5yfgYgmGH-FR2Rmo8EwY7Rn1nX-4VXyXgVipnu_dr3myK64iGauFpuQoh9_Ou78nGzssXcLzrV5cKl2BaXQ8o2qcKphUrRG5uLtUpne_c3dOhUyPb7dk7Q083149VdOb-__X01m5eakaovbTOtNdOsAmyxM9MGM8s4FTU3VaMpN8RpAQCcMU6s4bVTUDVmDMDclEBNJ-jiXXc1NK012nZ9UkGukm9V2siovPz30_mlXMS1nGLOMFSjwK-tQIovg829bH3WNgTV2ThkiWshGKYV5yP053_Q5zikbownscDAR1MURhR-R-kUc07W7cxgkG_lyU_ljZwf-yl2jI-26Ct6ypkX</recordid><startdate>20170513</startdate><enddate>20170513</enddate><creator>Gutiérrez-Gutiérrez, Filiberto</creator><creator>Puebla-Pérez, Ana María</creator><creator>González-Pozos, Sirenia</creator><creator>Hernández-Hernández, José Manuel</creator><creator>Pérez-Rangel, Armando</creator><creator>Alvarez, Laura Patricia</creator><creator>Tapia-Pastrana, Gabriela</creator><creator>Castillo-Romero, Araceli</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170513</creationdate><title>Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides</title><author>Gutiérrez-Gutiérrez, Filiberto ; Puebla-Pérez, Ana María ; González-Pozos, Sirenia ; Hernández-Hernández, José Manuel ; Pérez-Rangel, Armando ; Alvarez, Laura Patricia ; Tapia-Pastrana, Gabriela ; Castillo-Romero, Araceli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-eb68c4c4701e1fd6b14e453985d7bc35d2fc900054452ed58fa07bd0944f62083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adhesion</topic><topic>Antiprotozoal Agents - chemistry</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Antiviral drugs</topic><topic>Bursera - chemistry</topic><topic>Caco-2 Cells</topic><topic>Cell growth</topic><topic>Cell Survival - drug effects</topic><topic>Developing countries</topic><topic>Diarrhea</topic><topic>Drug dosages</topic><topic>Drugs</topic><topic>Electron microscopy</topic><topic>Epithelium</topic><topic>Flagella</topic><topic>Giardiasis</topic><topic>Humans</topic><topic>In vitro methods and tests</topic><topic>Inflammation</topic><topic>Inhibition</topic><topic>Intestine</topic><topic>LDCs</topic><topic>Lignans</topic><topic>Microscopy</topic><topic>Morphology</topic><topic>Parasites</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Podophyllotoxin</topic><topic>Podophyllotoxin - chemistry</topic><topic>Podophyllotoxin - pharmacology</topic><topic>Protozoa</topic><topic>Side effects</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gutiérrez-Gutiérrez, Filiberto</creatorcontrib><creatorcontrib>Puebla-Pérez, Ana María</creatorcontrib><creatorcontrib>González-Pozos, Sirenia</creatorcontrib><creatorcontrib>Hernández-Hernández, José Manuel</creatorcontrib><creatorcontrib>Pérez-Rangel, Armando</creatorcontrib><creatorcontrib>Alvarez, Laura Patricia</creatorcontrib><creatorcontrib>Tapia-Pastrana, Gabriela</creatorcontrib><creatorcontrib>Castillo-Romero, Araceli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gutiérrez-Gutiérrez, Filiberto</au><au>Puebla-Pérez, Ana María</au><au>González-Pozos, Sirenia</au><au>Hernández-Hernández, José Manuel</au><au>Pérez-Rangel, Armando</au><au>Alvarez, Laura Patricia</au><au>Tapia-Pastrana, Gabriela</au><au>Castillo-Romero, Araceli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2017-05-13</date><risdate>2017</risdate><volume>22</volume><issue>5</issue><spage>799</spage><pages>799-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects.
has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from
var.
, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the
adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity and low toxicity on Caco-2 cells. This finding makes it an attractive potential starting point for new antigiardial drugs.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28505094</pmid><doi>10.3390/molecules22050799</doi><oa>free_for_read</oa></addata></record> |
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subjects | Adhesion Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Antiviral drugs Bursera - chemistry Caco-2 Cells Cell growth Cell Survival - drug effects Developing countries Diarrhea Drug dosages Drugs Electron microscopy Epithelium Flagella Giardiasis Humans In vitro methods and tests Inflammation Inhibition Intestine LDCs Lignans Microscopy Morphology Parasites Plant Extracts - chemistry Plant Extracts - pharmacology Podophyllotoxin Podophyllotoxin - chemistry Podophyllotoxin - pharmacology Protozoa Side effects Toxicity |
title | Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides |
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