The role of high mobility group box 1 protein in acute cerebrovascular diseases

The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro-inflammatory factor that is expressed not only in the early-injury stage of disease, but also during the post-repair process. In the initial stag...

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Bibliographic Details
Published in:Biomedical reports 2018-09, Vol.9 (3), p.191-197
Main Authors: Mu, Shu-Wen, Dang, Yuan, Wang, Shou-Sen, Gu, Jian-Jun
Format: Article
Language:English
Subjects:
Amino acids
Apoptosis
Blood-brain barrier
Care and treatment
Cerebrovascular diseases
Cerebrovascular disorders
Cytoplasm
Deoxyribonucleic acid
Development and progression
Disease
DNA
Edema
Gene expression
Gene therapy
Genetic aspects
Hemorrhage
High mobility group proteins
HMGB1 protein
Inflammatory response
Ischemia
Kinases
Ligands
Mobility
Pathogenesis
Physiology
Proteins
Recovery
Repair
Review
Thrombosis
Tumor necrosis factor-TNF
Vascular diseases
Vasoconstriction
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Summary:The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro-inflammatory factor that is expressed not only in the early-injury stage of disease, but also during the post-repair process. In the initial stage of disease, HMGB1 is released into the outside of the cell to participate in the cascade amplification reaction of inflammation, causing vasospasm, destruction of the blood-brain barrier and apoptosis of nerve cells. In the recovery stage of disease, HMGB1 can promote tissue repair and remodeling, which can aid in nerve function recovery. This review summarizes the biological characteristics of HMGB1, and the role of HMGB1 in ischemic and hemorrhagic cerebrovascular disease, and cerebral venous thrombosis.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2018.1127