The role of high mobility group box 1 protein in acute cerebrovascular diseases

The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro-inflammatory factor that is expressed not only in the early-injury stage of disease, but also during the post-repair process. In the initial stag...

Full description

Saved in:
Bibliographic Details
Published in:Biomedical reports 2018-09, Vol.9 (3), p.191-197
Main Authors: Mu, Shu-Wen, Dang, Yuan, Wang, Shou-Sen, Gu, Jian-Jun
Format: Article
Language:English
Subjects:
Amino acids
Apoptosis
Blood-brain barrier
Care and treatment
Cerebrovascular diseases
Cerebrovascular disorders
Cytoplasm
Deoxyribonucleic acid
Development and progression
Disease
DNA
Edema
Gene expression
Gene therapy
Genetic aspects
Hemorrhage
High mobility group proteins
HMGB1 protein
Inflammatory response
Ischemia
Kinases
Ligands
Mobility
Pathogenesis
Physiology
Proteins
Recovery
Repair
Review
Thrombosis
Tumor necrosis factor-TNF
Vascular diseases
Vasoconstriction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c545t-624500c0387f778b7ef7b75a814a6a4b7bb768915fbe094e35f8eba73e1bcb293
cites cdi_FETCH-LOGICAL-c545t-624500c0387f778b7ef7b75a814a6a4b7bb768915fbe094e35f8eba73e1bcb293
container_end_page 197
container_issue 3
container_start_page 191
container_title Biomedical reports
container_volume 9
creator Mu, Shu-Wen
Dang, Yuan
Wang, Shou-Sen
Gu, Jian-Jun
description The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro-inflammatory factor that is expressed not only in the early-injury stage of disease, but also during the post-repair process. In the initial stage of disease, HMGB1 is released into the outside of the cell to participate in the cascade amplification reaction of inflammation, causing vasospasm, destruction of the blood-brain barrier and apoptosis of nerve cells. In the recovery stage of disease, HMGB1 can promote tissue repair and remodeling, which can aid in nerve function recovery. This review summarizes the biological characteristics of HMGB1, and the role of HMGB1 in ischemic and hemorrhagic cerebrovascular disease, and cerebral venous thrombosis.
doi_str_mv 10.3892/br.2018.1127
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6158396</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A554909048</galeid><sourcerecordid>A554909048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c545t-624500c0387f778b7ef7b75a814a6a4b7bb768915fbe094e35f8eba73e1bcb293</originalsourceid><addsrcrecordid>eNptks9rHCEUx6U0NCHJreci9NJDduvPUS-FENIkEMglPYu6z13DzLjVmdD893VJuk1KfYIP_byvPP0i9JGSJdeGffVlyQjVS0qZeoeOGBFmYYRg7_c5F4fotNYH0oZRhEn9AR1ywhSVhh-hu_sN4JJ7wDniTVpv8JB96tP0hNclz1vs8y9M8bbkCdKI23RhngAHKOBLfnQ1zL0reJUquAr1BB1E11c4fVmP0Y_vl_cX14vbu6ubi_PbRZBCTouOCUlIIFyrqJT2CqLySjpNheuc8Mp71WlDZfRAjAAuowbvFAfqg2eGH6Nvz7rb2Q-wCjBOxfV2W9LgypPNLtm3J2Pa2HV-tB2VmpuuCXx5ESj55wx1skOqAfrejZDnahmlkikiO9nQz_-gD3kuY2vPMmIMM8pQ8pdaux5sGmNu94adqD2XUhhiiNCNWv6HarGCIYU8Qkxt_03B2XNBKLnWAnHfIyV25wHri915wO480PBPr99lD__5cf4bXkeqxA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2099297910</pqid></control><display><type>article</type><title>The role of high mobility group box 1 protein in acute cerebrovascular diseases</title><source>PubMed Central Free</source><creator>Mu, Shu-Wen ; Dang, Yuan ; Wang, Shou-Sen ; Gu, Jian-Jun</creator><creatorcontrib>Mu, Shu-Wen ; Dang, Yuan ; Wang, Shou-Sen ; Gu, Jian-Jun</creatorcontrib><description>The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro-inflammatory factor that is expressed not only in the early-injury stage of disease, but also during the post-repair process. In the initial stage of disease, HMGB1 is released into the outside of the cell to participate in the cascade amplification reaction of inflammation, causing vasospasm, destruction of the blood-brain barrier and apoptosis of nerve cells. In the recovery stage of disease, HMGB1 can promote tissue repair and remodeling, which can aid in nerve function recovery. This review summarizes the biological characteristics of HMGB1, and the role of HMGB1 in ischemic and hemorrhagic cerebrovascular disease, and cerebral venous thrombosis.</description><identifier>ISSN: 2049-9434</identifier><identifier>EISSN: 2049-9442</identifier><identifier>DOI: 10.3892/br.2018.1127</identifier><identifier>PMID: 30271593</identifier><language>eng</language><publisher>England: Spandidos Publications</publisher><subject>Amino acids ; Apoptosis ; Blood-brain barrier ; Care and treatment ; Cerebrovascular diseases ; Cerebrovascular disorders ; Cytoplasm ; Deoxyribonucleic acid ; Development and progression ; Disease ; DNA ; Edema ; Gene expression ; Gene therapy ; Genetic aspects ; Hemorrhage ; High mobility group proteins ; HMGB1 protein ; Inflammatory response ; Ischemia ; Kinases ; Ligands ; Mobility ; Pathogenesis ; Physiology ; Proteins ; Recovery ; Repair ; Review ; Thrombosis ; Tumor necrosis factor-TNF ; Vascular diseases ; Vasoconstriction</subject><ispartof>Biomedical reports, 2018-09, Vol.9 (3), p.191-197</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Mu et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-624500c0387f778b7ef7b75a814a6a4b7bb768915fbe094e35f8eba73e1bcb293</citedby><cites>FETCH-LOGICAL-c545t-624500c0387f778b7ef7b75a814a6a4b7bb768915fbe094e35f8eba73e1bcb293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158396/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158396/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30271593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mu, Shu-Wen</creatorcontrib><creatorcontrib>Dang, Yuan</creatorcontrib><creatorcontrib>Wang, Shou-Sen</creatorcontrib><creatorcontrib>Gu, Jian-Jun</creatorcontrib><title>The role of high mobility group box 1 protein in acute cerebrovascular diseases</title><title>Biomedical reports</title><addtitle>Biomed Rep</addtitle><description>The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro-inflammatory factor that is expressed not only in the early-injury stage of disease, but also during the post-repair process. In the initial stage of disease, HMGB1 is released into the outside of the cell to participate in the cascade amplification reaction of inflammation, causing vasospasm, destruction of the blood-brain barrier and apoptosis of nerve cells. In the recovery stage of disease, HMGB1 can promote tissue repair and remodeling, which can aid in nerve function recovery. This review summarizes the biological characteristics of HMGB1, and the role of HMGB1 in ischemic and hemorrhagic cerebrovascular disease, and cerebral venous thrombosis.</description><subject>Amino acids</subject><subject>Apoptosis</subject><subject>Blood-brain barrier</subject><subject>Care and treatment</subject><subject>Cerebrovascular diseases</subject><subject>Cerebrovascular disorders</subject><subject>Cytoplasm</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>Disease</subject><subject>DNA</subject><subject>Edema</subject><subject>Gene expression</subject><subject>Gene therapy</subject><subject>Genetic aspects</subject><subject>Hemorrhage</subject><subject>High mobility group proteins</subject><subject>HMGB1 protein</subject><subject>Inflammatory response</subject><subject>Ischemia</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Mobility</subject><subject>Pathogenesis</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Recovery</subject><subject>Repair</subject><subject>Review</subject><subject>Thrombosis</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vascular diseases</subject><subject>Vasoconstriction</subject><issn>2049-9434</issn><issn>2049-9442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNptks9rHCEUx6U0NCHJreci9NJDduvPUS-FENIkEMglPYu6z13DzLjVmdD893VJuk1KfYIP_byvPP0i9JGSJdeGffVlyQjVS0qZeoeOGBFmYYRg7_c5F4fotNYH0oZRhEn9AR1ywhSVhh-hu_sN4JJ7wDniTVpv8JB96tP0hNclz1vs8y9M8bbkCdKI23RhngAHKOBLfnQ1zL0reJUquAr1BB1E11c4fVmP0Y_vl_cX14vbu6ubi_PbRZBCTouOCUlIIFyrqJT2CqLySjpNheuc8Mp71WlDZfRAjAAuowbvFAfqg2eGH6Nvz7rb2Q-wCjBOxfV2W9LgypPNLtm3J2Pa2HV-tB2VmpuuCXx5ESj55wx1skOqAfrejZDnahmlkikiO9nQz_-gD3kuY2vPMmIMM8pQ8pdaux5sGmNu94adqD2XUhhiiNCNWv6HarGCIYU8Qkxt_03B2XNBKLnWAnHfIyV25wHri915wO480PBPr99lD__5cf4bXkeqxA</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Mu, Shu-Wen</creator><creator>Dang, Yuan</creator><creator>Wang, Shou-Sen</creator><creator>Gu, Jian-Jun</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>The role of high mobility group box 1 protein in acute cerebrovascular diseases</title><author>Mu, Shu-Wen ; Dang, Yuan ; Wang, Shou-Sen ; Gu, Jian-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-624500c0387f778b7ef7b75a814a6a4b7bb768915fbe094e35f8eba73e1bcb293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amino acids</topic><topic>Apoptosis</topic><topic>Blood-brain barrier</topic><topic>Care and treatment</topic><topic>Cerebrovascular diseases</topic><topic>Cerebrovascular disorders</topic><topic>Cytoplasm</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>Disease</topic><topic>DNA</topic><topic>Edema</topic><topic>Gene expression</topic><topic>Gene therapy</topic><topic>Genetic aspects</topic><topic>Hemorrhage</topic><topic>High mobility group proteins</topic><topic>HMGB1 protein</topic><topic>Inflammatory response</topic><topic>Ischemia</topic><topic>Kinases</topic><topic>Ligands</topic><topic>Mobility</topic><topic>Pathogenesis</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Recovery</topic><topic>Repair</topic><topic>Review</topic><topic>Thrombosis</topic><topic>Tumor necrosis factor-TNF</topic><topic>Vascular diseases</topic><topic>Vasoconstriction</topic><toplevel>online_resources</toplevel><creatorcontrib>Mu, Shu-Wen</creatorcontrib><creatorcontrib>Dang, Yuan</creatorcontrib><creatorcontrib>Wang, Shou-Sen</creatorcontrib><creatorcontrib>Gu, Jian-Jun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedical reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mu, Shu-Wen</au><au>Dang, Yuan</au><au>Wang, Shou-Sen</au><au>Gu, Jian-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of high mobility group box 1 protein in acute cerebrovascular diseases</atitle><jtitle>Biomedical reports</jtitle><addtitle>Biomed Rep</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>9</volume><issue>3</issue><spage>191</spage><epage>197</epage><pages>191-197</pages><issn>2049-9434</issn><eissn>2049-9442</eissn><abstract>The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro-inflammatory factor that is expressed not only in the early-injury stage of disease, but also during the post-repair process. In the initial stage of disease, HMGB1 is released into the outside of the cell to participate in the cascade amplification reaction of inflammation, causing vasospasm, destruction of the blood-brain barrier and apoptosis of nerve cells. In the recovery stage of disease, HMGB1 can promote tissue repair and remodeling, which can aid in nerve function recovery. This review summarizes the biological characteristics of HMGB1, and the role of HMGB1 in ischemic and hemorrhagic cerebrovascular disease, and cerebral venous thrombosis.</abstract><cop>England</cop><pub>Spandidos Publications</pub><pmid>30271593</pmid><doi>10.3892/br.2018.1127</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2049-9434
ispartof Biomedical reports, 2018-09, Vol.9 (3), p.191-197
issn 2049-9434
2049-9442
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6158396
source PubMed Central Free
subjects Amino acids
Apoptosis
Blood-brain barrier
Care and treatment
Cerebrovascular diseases
Cerebrovascular disorders
Cytoplasm
Deoxyribonucleic acid
Development and progression
Disease
DNA
Edema
Gene expression
Gene therapy
Genetic aspects
Hemorrhage
High mobility group proteins
HMGB1 protein
Inflammatory response
Ischemia
Kinases
Ligands
Mobility
Pathogenesis
Physiology
Proteins
Recovery
Repair
Review
Thrombosis
Tumor necrosis factor-TNF
Vascular diseases
Vasoconstriction
title The role of high mobility group box 1 protein in acute cerebrovascular diseases
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T20%3A55%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20high%20mobility%20group%20box%201%20protein%20in%20acute%20cerebrovascular%20diseases&rft.jtitle=Biomedical%20reports&rft.au=Mu,%20Shu-Wen&rft.date=2018-09-01&rft.volume=9&rft.issue=3&rft.spage=191&rft.epage=197&rft.pages=191-197&rft.issn=2049-9434&rft.eissn=2049-9442&rft_id=info:doi/10.3892/br.2018.1127&rft_dat=%3Cgale_pubme%3EA554909048%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c545t-624500c0387f778b7ef7b75a814a6a4b7bb768915fbe094e35f8eba73e1bcb293%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2099297910&rft_id=info:pmid/30271593&rft_galeid=A554909048&rfr_iscdi=true