The iron hand of uropathogenic Escherichia coli: the role of transition metal control in virulence

The role of iron as a critical nutrient in pathogenic bacteria is widely regarded as having driven selection for iron acquisition systems among uropathogenic Escherichia coli (UPEC) isolates. Carriage of multiple transition metal acquisition systems in UPEC suggests that the human urinary tract mani...

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Bibliographic Details
Published in:Future microbiology 2018-06, Vol.13 (7), p.745-756
Main Authors: Robinson, Anne E, Heffernan, James R, Henderson, Jeffrey P
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Bacteria
E coli
Enzymes
Escherichia coli
Escherichia coli Infections - microbiology
Escherichia coli Proteins - genetics
Escherichia coli Proteins - metabolism
Genetic engineering
Homeostasis
Humans
Iron
Iron - metabolism
Kidneys
Metal ions
Nutrients
Pathogenesis
Pathogens
Patients
Proteins
Review
Sepsis
Siderophores - metabolism
Urinary tract
Urinary tract diseases
Urinary tract infections
Urine
Urogenital system
Uropathogenic Escherichia coli - genetics
Uropathogenic Escherichia coli - metabolism
Uropathogenic Escherichia coli - pathogenicity
Virulence
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Summary:The role of iron as a critical nutrient in pathogenic bacteria is widely regarded as having driven selection for iron acquisition systems among uropathogenic Escherichia coli (UPEC) isolates. Carriage of multiple transition metal acquisition systems in UPEC suggests that the human urinary tract manipulates metal-ion availability in many ways to resist infection. For siderophore systems in particular, recent studies have identified new roles for siderophore copper binding as well as production of siderophore-like inhibitors of iron uptake by other, competing bacterial species. Among these is a process of nutritional passivation of metal ions, in which uropathogens access these vital nutrients while simultaneously protecting themselves from their toxic potential. Here, we review these new findings within the current understanding of UPEC transition metal acquisition.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2017-0295