Chromogenic Multiplex Immunohistochemistry Reveals Modulation of the Immune Microenvironment Associated with Survival in Elderly Patients with Lung Adenocarcinoma

With underrepresentation of elderly patients with lung adenocarcinoma (LADC) in anti-PD-1/PD-L1 clinical trials, better understanding of the interplay of PD-L1 and tumor-associated immune cells (TAICs) could assist clinicians in stratifying these patients for immunotherapy. One hundred and one patie...

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Published in:Cancers 2018-09, Vol.10 (9), p.326
Main Authors: Ilié, Marius, Beaulande, Mélanie, Ben Hadj, Saima, Chamorey, Emmanuel, Schiappa, Renaud, Long-Mira, Elodie, Lassalle, Sandra, Butori, Catherine, Cohen, Charlotte, Leroy, Sylvie, Guérin, Olivier, Mouroux, Jérôme, Marquette, Charles-Hugo, Pomerol, Jean-François, Erb, Gilles, Hofman, Véronique, Hofman, Paul
Format: Article
Language:English
Subjects:
Adenocarcinoma
Age
Aging
Automation
Biomarkers
CD4 antigen
CD8 antigen
Clinical trials
Geriatrics
Immunohistochemistry
Immunotherapy
Labeling
Ligands
Lung cancer
Lymphocytes
Microenvironments
Patients
PD-1 protein
PD-L1 protein
Thoracic surgery
Tumor cells
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Summary:With underrepresentation of elderly patients with lung adenocarcinoma (LADC) in anti-PD-1/PD-L1 clinical trials, better understanding of the interplay of PD-L1 and tumor-associated immune cells (TAICs) could assist clinicians in stratifying these patients for immunotherapy. One hundred and one patients with LADCs, stratified by age, were included for analysis of PD-L1 expression and density of TAICs expressing CD4, CD8, and CD33, by using multiplex chromogenic immunohistochemistry (IHC) assays and automated digital quantification. The CD4⁺/CD8⁺ ratio was significantly higher in elderly patients. In patients
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers10090326