The Cutaneous Microbiome and Wounds: New Molecular Targets to Promote Wound Healing

• Published in: International journal of molecular sciences 2018-09, Vol.19 (9), p.2699
• Main Authors: Johnson, Taylor R, Gómez, Belinda I, McIntyre, Matthew K, Dubick, Michael A, Christy, Robert J, Nicholson, Susannah E, Burmeister, David M
• Format: Article
• Language: English
• Subjects: Animals; Anti-Infective Agents - therapeutic use; Antibiotics; Antimicrobial agents; Bacteria; Biofilms; Commensals; Genomes; Homeostasis; Humans; Immune system; Inflammation; Inflammatory response; Intestinal microflora; Literature reviews; Microbiomes; Microbiota; Microbiota - drug effects; Microorganisms; Peptides; Probiotics; Probiotics - therapeutic use; Review; Ribosomal DNA; Skin; Skin - microbiology; Staphylococcus infections; Symbionts; Systematic review; Tissue engineering; Viruses; Wound healing; Wound Healing - drug effects; Wound Infection - drug therapy; Wound Infection - microbiology; Wound Infection - therapy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms19092699

The ecological community of microorganisms in/on humans, termed the microbiome, is vital for sustaining homeostasis. While culture-independent techniques have revealed the role of the gut microbiome in human health and disease, the role of the cutaneous microbiome in wound healing is less defined. Skin commensals are essential in the maintenance of the epithelial barrier function, regulation of the host immune system, and protection from invading pathogenic microorganisms. In this review, we summarize the literature derived from pre-clinical and clinical studies on how changes in the microbiome of various acute and chronic skin wounds impact wound healing tissue regeneration. Furthermore, we review the mechanistic insights garnered from model wound healing systems. Finally, in the face of growing concern about antibiotic-resistance, we will discuss alternative strategies for the treatment of infected wounds to improve wound healing and outcomes. Taken together, it has become apparent that commensals, symbionts, and pathogens on human skin have an intimate role in the inflammatory response that highlights several potential strategies to treat infected, non-healing wounds. Despite these promising results, there are some contradictory and controversial findings from existing studies and more research is needed to define the role of the human skin microbiome in acute and chronic wound healing.