Injectable Hydrogels for Cardiac Tissue Engineering

In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio‐protective molecules, and improve cell‐based therapeutic techniques. Injectab...

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Bibliographic Details
Published in:Macromolecular bioscience 2018-06, Vol.18 (6), p.e1800079-n/a
Main Authors: Peña, Brisa, Laughter, Melissa, Jett, Susan, Rowland, Teisha J., Taylor, Matthew R. G., Mestroni, Luisa, Park, Daewon
Format: Article
Language:English
Subjects:
Alginates
Alginates - chemistry
Alginates - therapeutic use
Alginic acid
Animals
Biomimetic materials
cardiac regeneration
cardiac tissue engineering
Design engineering
Heart
Heart diseases
Heart Ventricles - metabolism
Humans
Hydrogels
Hydrogels - chemistry
Hydrogels - therapeutic use
injectable hydrogels
Molecular chains
Myocardial infarction
Myocardium - metabolism
Preservation
Regeneration
Stroke Volume - drug effects
Tissue engineering
Tissue Engineering - methods
Ventricle
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Summary:In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio‐protective molecules, and improve cell‐based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate‐based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF). This review provides an overview of recent developments that have occurred in the design and engineering of various injectable hydrogel systems for cardiac tissue engineering efforts, including a comparison of natural versus synthetic systems with emphasis on the ideal characteristics for biomimetic cardiac materials. Injectable hydrogels for cardiac tissue engineering can be used for in vitro models, in vivo preclinical purposes, and for clinical trials.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.201800079