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LINC00152 Promotes Invasion through a 3'-Hairpin Structure and Associates with Prognosis in Glioblastoma
Long noncoding RNAs (lncRNA) are increasingly implicated in oncogenesis. Here, it is determined that / is upregulated in glioblastoma multiforme (GBM) and aggressive wild-type IDH1/2 grade 2/3 gliomas and upregulation associates with poor patient outcomes. is similarly upregulated in over 10 other c...
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Published in: | Molecular cancer research 2018-10, Vol.16 (10), p.1470-1482 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Long noncoding RNAs (lncRNA) are increasingly implicated in oncogenesis. Here, it is determined that
/
is upregulated in glioblastoma multiforme (GBM) and aggressive wild-type IDH1/2 grade 2/3 gliomas and upregulation associates with poor patient outcomes.
is similarly upregulated in over 10 other cancer types and associates with a poor prognosis in 7 other cancer types. Inhibition of the mostly cytoplasmic
decreases, and overexpression increases cellular invasion.
knockdown alters the transcription of genes important to epithelial-to-mesenchymal transition (EMT). PARIS and Ribo-seq data, together with secondary structure prediction, identified a protein-bound 121-bp stem-loop structure at the 3' end of
whose overexpression is sufficient to increase invasion of GBM cells. Point mutations in the stem-loop suggest that stem formation in the hairpin is essential for
function.
has a nearly identical homolog,
, which encodes a near identical hairpin, is equally expressed in low-grade glioma (LGG) and GBM, predicts poor patient survival in these tumors, and is also reduced by
knockdown. Together, these data reveal that
and its homolog
associate with aggressive tumors and promote cellular invasion through a mechanism that requires the structural integrity of a hairpin structure.
Frequent upregulation of the lncRNA,
, in glioblastoma and other tumor types combined with its prognostic potential and ability to promote invasion suggests
as a potential biomarker and therapeutic target.
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ISSN: | 1541-7786 1557-3125 |
DOI: | 10.1158/1541-7786.MCR-18-0322 |