Biphasic low-grade nasopharyngeal papillary adenocarcinoma: a case report and literature review

Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is distinctly rare. We report a patient with a uniquely biphasic LGNPPA; additionally, we review similar tumors reported in the literature. A 56-year-old man presented with an asymptomatic pedunculated tumor in the vault of the nasopharynx,...

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Published in:BMC clinical pathology 2018-10, Vol.18 (1), p.10, Article 10
Main Authors: Yokoi, Hidenori, Terado, Yuichi, Fujiwara, Masachika, Matsumoto, Yuma, Ikeda, Tetsuya, Saito, Koichiro
Format: Article
Language:English
Subjects:
Adenocarcinoma
Anesthesia
Cancer screening
Case Report
Case reports
Endoscopy
Human papillomavirus
Immunohistochemistry
Laryngeal cancer
Literature reviews
Medical imaging
Nasopharynx
NMR
Nuclear magnetic resonance
Pathology
Septum
Surgery
Thyroid gland
Transcription factors
Tumors
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creator Yokoi, Hidenori
Terado, Yuichi
Fujiwara, Masachika
Matsumoto, Yuma
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Saito, Koichiro
description Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is distinctly rare. We report a patient with a uniquely biphasic LGNPPA; additionally, we review similar tumors reported in the literature. A 56-year-old man presented with an asymptomatic pedunculated tumor in the vault of the nasopharynx, at the junction of the nasal septum and the roof, which was discovered during screening for laryngeal cancer. To obtain a definitive diagnosis, the patient underwent endoscopic endonasal surgery under general anesthesia. Immunohistochemical analysis of the tumor revealed it to be an LGNPPA with a prominent spindle cell component. To our knowledge, this is the fourth reported LGNPPA exhibiting a spindle cell component and the second with a prominent pathological condition. The prognosis of LGNPPA is usually excellent. Therefore, it is important for clinicians to scrutinize the lesion's pathology to avoid unnecessary, disfiguring surgery.
doi_str_mv 10.1186/s12907-018-0076-1
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subjects Adenocarcinoma
Anesthesia
Cancer screening
Case Report
Case reports
Endoscopy
Human papillomavirus
Immunohistochemistry
Laryngeal cancer
Literature reviews
Medical imaging
Nasopharynx
NMR
Nuclear magnetic resonance
Pathology
Septum
Surgery
Thyroid gland
Transcription factors
Tumors
title Biphasic low-grade nasopharyngeal papillary adenocarcinoma: a case report and literature review
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