Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study

We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D). A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammat...

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Published in:Journal of diabetes and its complications 2018-11, Vol.32 (11), p.995-999
Main Authors: Alman, Amy C., Talton, Jennifer W., Wadwa, R. Paul, Urbina, Elaine M., Dolan, Lawrence M., Hamman, Richard F., D'Agostino, Ralph B., Marcovina, Santica M., Dabelea, Dana M.
Format: Article
Language:English
Subjects:
Age
Arterial stiffness
Atherosclerosis
Cardiovascular disease
Cholesterol
Cytokines
Diabetes
Fibrinogen
Inflammation
Insulin resistance
Laboratories
Lipoproteins
Metabolism
Population
Proteins
Pulse wave analysis
Teenagers
Triglycerides
Type 1 diabetes mellitus
Waist circumference
Young adults
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Summary:We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D). A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later. PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p 
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2018.08.004