Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome

Nephrotic syndrome is a disorder caused by kidney damage that results in severe leakage of protein from blood into urine. Hyperlipidemia is one complication of nephrotic syndrome. L-carnitine and genistein can control cardiovascular diseases by causing changes in lipid metabolism and cytokine produc...

Full description

Saved in:
Bibliographic Details
Published in:Reports of biochemistry and molecular biology 2018-10, Vol.7 (1), p.1-8
Main Authors: Yousefinejad, Abbas, Siassi, Fereydoon, Javanbakht, Mohammad Hassan, Mohammadi, Hamed, Ghaedi, Ehsan, Zarei, Mahnaz, Djalali, Ehsan, Djalali, Mahmoud
Format: Article
Language:English
Subjects:
Original
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nephrotic syndrome is a disorder caused by kidney damage that results in severe leakage of protein from blood into urine. Hyperlipidemia is one complication of nephrotic syndrome. L-carnitine and genistein can control cardiovascular diseases by causing changes in lipid metabolism and cytokine production. This study was designed to examine the effects of genistein and L-carnitine on serum lipid and cytokine profiles in experimental nephrotic syndrome. In this study, 50 male Sprague-Dawley rats were randomly divided into five groups of 10 animals each with similar mean body weights (300±50 g). The five groups were NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), and LCG (L-carnitine-genistein). Serum HDL-cholesterol (HDL) LDL-cholesterol (LDL), triglyceride, cholesterol, IL-6, and TNF-α were measured. Statistics were analyzed using SPSS 18.0. At the end of the study, of the patient groups, HDL was significantly greater in the LC than in the PC or G groups (P
ISSN:2322-3480
2322-3480