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Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome

The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, incr...

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Published in:World journal of gastroenterology : WJG 2018-10, Vol.24 (37), p.4217-4223
Main Authors: Camara-Lemarroy, Carlos R, Metz, Luanne M, Yong, V Wee
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Language:English
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creator Camara-Lemarroy, Carlos R
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description The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results.
doi_str_mv 10.3748/wjg.v24.i37.4217
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subjects Animals
Bile Acids and Salts - chemistry
Brain - physiopathology
Central Nervous System - physiology
Clinical Trials as Topic
Fecal Microbiota Transplantation
Gastrointestinal Microbiome
Gastrointestinal Tract
Humans
Immune System
Intestines - physiology
Multiple Sclerosis - microbiology
Multiple Sclerosis - physiopathology
Probiotics
title Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome
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