Potential function of CTLA-4 in the tumourigenic capacity of melanoma stem cells

Extensive clinical evidence supports that cytotoxic T lymphocyte antigen-4 (CTLA-4) is expressed in a variety of human malignant tumour cells in addition to T cells. In certain types of cancer, the overexpression of CTLA-4 is associated with poor patient prognosis. However, few studies have demonstr...

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Bibliographic Details
Published in:Oncology letters 2018-11, Vol.16 (5), p.6163-6170
Main Authors: Zhang, Bingyu, Dang, Jianzhong, Ba, Diandian, Wang, Cencen, Han, Juan, Zheng, Fang
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Enzymes
Flow cytometry
Growth factors
Medical prognosis
Melanoma
Skin cancer
Stem cells
Studies
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Summary:Extensive clinical evidence supports that cytotoxic T lymphocyte antigen-4 (CTLA-4) is expressed in a variety of human malignant tumour cells in addition to T cells. In certain types of cancer, the overexpression of CTLA-4 is associated with poor patient prognosis. However, few studies have demonstrated the effects of tumour-intrinsic CTLA-4 in cancer stem cells, including melanoma stem cells (MSCs). In the present study, it was demonstrated that melanoma cell-intrinsic CTLA-4 induced tumour cell proliferation and suppressed tumour cell apoptosis. Furthermore, CTLA-4 was expressed in aldehyde dehydrogenase (ALDH)+ MSCs. CTLA-4 inhibited MSCs proliferation by blocking antibodies and significantly downregulated ALDH1A1, ALDH1A3 and ALDH2 mRNA expression (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9354