Getting MAD at MYC

Torchia and Ashwell express commentary on the study by Li et al identify a molecular mechanism for the regulation of c-MYC expression and function and describe a small molecule that inhibits MYC by enhancing the expression of a functional MYC antagonist in the transcriptional regulatory network. The...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2018-10, Vol.115 (40), p.9821-9823
Main Authors: Torchia, Maria Letizia Giardino, Ashwell, Jonathan D.
Format: Article
Language:English
Subjects:
Adenine Nucleotides
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Basic-Leucine Zipper Transcription Factors
Biological Sciences
c-Myc protein
Commentaries
COMMENTARY
Deoxyribonucleic acid
DNA
DNA-Binding Proteins
Gene expression
Genomes
Molecular biology
Myc protein
Mycophenolic Acid - analogs & derivatives
Proto-Oncogene Proteins c-myc
Reagents
Repressor Proteins
Transcription Factors
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Summary:Torchia and Ashwell express commentary on the study by Li et al identify a molecular mechanism for the regulation of c-MYC expression and function and describe a small molecule that inhibits MYC by enhancing the expression of a functional MYC antagonist in the transcriptional regulatory network. The study uses the functional interplay between cIAP1 and MAD1 as a starting point to develop reagents that reverse the cell growth-promoting effects of MYC. MYC protooncogene family (MYC, MYCN, and MYCL), known variously as super, master, or global transcription factors, affects the expression of an estimated 15% of the entire genome, which may in fact be an underestimate, given that Myc accumulates not just at specific DNA target sites but also in the promoter regions of most actively transcribed genes and leads to their amplification.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1813867115