Serial imaging after pulmonary embolism and correlation with functional limitation at 12 months: Results of the ELOPE Study

Unlabelled Box Risk factors for exercise limitation after acute pulmonary embolism (PE) are unknown. As a planned sub‐study of the prospective, multicenter ELOPE (Evaluation of Long‐term Outcomes after PE) Study, we aimed to describe the results of serial imaging by computed tomography pulmonary ang...

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Bibliographic Details
Published in:Research and practice in thrombosis and haemostasis 2018-10, Vol.2 (4), p.670-677
Main Authors: Ma, Kim A., Kahn, Susan R., Akaberi, Arash, Dennie, Carole, Rush, Christopher, Granton, John T., Anderson, David, Wells, Philip S., Rodger, Marc A., Solymoss, Susan, Kovacs, Michael J., Rudski, Lawrence, Shimony, Avi, Hernandez, Paul, Aaron, Shawn D., Pena, Elena, Abikhzer, Gad, Hirsch, Andrew M.
Format: Article
Language:English
Subjects:
Anticoagulants
CT pulmonary angiography
dyspnea
Embolisms
Exercise
exercise test
Mortality
Original
Original : Thrombosis
Patients
Pulmonary arteries
pulmonary embolism
Pulmonary embolisms
Pulmonary hypertension
Studies
Thromboembolism
thrombosis
Veins & arteries
Ventilation
ventilation/perfusion lung scan
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Summary:Unlabelled Box Risk factors for exercise limitation after acute pulmonary embolism (PE) are unknown. As a planned sub‐study of the prospective, multicenter ELOPE (Evaluation of Long‐term Outcomes after PE) Study, we aimed to describe the results of serial imaging by computed tomography pulmonary angiography (CTPA) and perfusion scan during 1 year after a first episode of acute pulmonary embolism, and to assess the association between imaging parameters and exercise limitation at 1 year. In a prospective cohort study, 100 patients were recruited between June 2010 and February 2013 at five Canadian university–affiliated hospitals. CT pulmonary angiography was performed at baseline and 12 months, perfusion scan at 6 and 12 months, and cardio‐pulmonary exercise testing at 1 and 12 months. Imaging parameters included: on CT pulmonary angiography, CT obstruction index (CTO) (% clot burden in the pulmonary vasculature), and on perfusion scan, pulmonary vascular obstruction (PVO) (% perfusion defect). Abnormal cardio‐pulmonary exercise test (primary outcome) was defined as percent of predicted peak oxygen uptake (VO2)
ISSN:2475-0379
2475-0379
DOI:10.1002/rth2.12123