Evaluation of the metabolic response to open and minimally invasive resection of the oesophagus due to oesophageal cancer

• Published in: Kardiochirurgia i torakochirurgia polska 2018-09, Vol.15 (3), p.151-156
• Main Authors: Pieróg, Jarosław, Bielewicz, Michał, Wójcik, Janusz, Kubisa, Bartosz, Kaseja, Krzysztof, Safranow, Krzysztof, Dołęgowska, Barbara, Waloszczyk, Piotr, Grodzki, Tomasz
• Format: Article
• Language: English
• Subjects: C-reactive protein; Cancer; Esophageal cancer; Esophagus; Gangrene; Interleukin 6; Laparoscopy; Metabolic response; Metabolism; Original Paper; Ostomy; Procalcitonin; Surgery; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumors
• ISSN: 1731-5530; 1897-4252
• DOI: 10.5114/kitp.2018.78438

The aim of this study was to compare the metabolic response in the early postoperative period after radical resection of stage I and II oesophageal cancer applying a minimally invasive procedure and an open procedure involving classical laparotomy and thoracotomy. Serum concentrations of interleukin 6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), and total serum protein (TP) and leukocyte count (WBC) in blood collected on the day of surgery prior to the procedure (day 0) and on days 1, 2 and 7 after the surgery were measured in two groups of patients undergoing oesophageal resection due to cancer: applying a minimally invasive procedure involving laparoscopy and videothoracoscopy (group A) and applying a classical procedure involving full opening of the chest and abdominal cavity (group B). The study involved a total of 24 patients divided into two groups of 12 patients each. Tumour necrosis factor-α concentration was lower in group A compared to group B on day 0, PCT concentration was lower in group A compared to group B on day 2 after surgery, and on the remaining days TNF-α and PCT concentrations were not statistically different between groups. Lower concentration of PCT on post-surgery day 2 in the group of patients undergoing minimally invasive oesophageal resection seems to be associated with a smaller perioperative injury. Lower TNF-α concentration in serum collected on day 0 in the group of patients undergoing minimally invasive resection is associated with a lower stage of oesophageal cancer in this group.