Lower circulating angiotensin II levels are related to the severity of preeclampsia and its risk as disclosed by a specific bioassay

• Published in: Medicine (Baltimore) 2018-09, Vol.97 (39), p.e12498-e12498
• Main Authors: Leaños-Miranda, Alfredo, Inova Campos-Galicia, Méndez-Aguilar, Francisco, Molina-Pérez, Carlos José, Ramírez-Valenzuela, Karla Leticia, Sillas-Pardo, Liliana Janet, Uraga-Camacho, Navid Claudian, Isordia-Salas, Irma, Berumen-Lechuga, María Guadalupe
• Format: Article
• Language: English
• Subjects: Adult; Angiotensin II - analysis; Angiotensin II - blood; Biological Assay - methods; Blood Pressure - physiology; Blood Pressure Determination; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Mexico; Observational Study; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Pre-Eclampsia - epidemiology; Predictive Value of Tests; Pregnancy; Reproducibility of Results; Risk Assessment - methods; Severity of Illness Index; Statistics as Topic
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/md.0000000000012498

Preeclampsia is characterized by an increased sensitivity to angiotensin II (Ang II). We herein assessed whether serum Ang II levels measured by a new developed bioassay are associated with preeclampsia, its severity, and the risk for developing this disease.Using a cross-sectional design, we studied 90 pregnant women (30 healthy pregnant and 60 with preeclampsia [30 with- and 30 without severe features]). We also used a nested case-control study with 30 women who eventually developed preeclampsia and 31 normotensive controls. Serum samples were collected at diagnosis of preeclampsia or at 4-week intervals (from weeks 12th to 36th). Ang II was measured using a bioassay.At diagnosis of preeclampsia, serum Ang II concentrations were significantly lower in preeclampsia without and with severe features (P = .001 and P