Measurement of urinary biomarkers in a case of tubulointerstitial nephritis and uveitis syndrome during glucocorticoid treatment

Tubulointerstitial nephritis and uveitis (TINU) is a rare syndrome in which idiopathic interstitial nephritis coexists with chronic recurrent uveitis. This syndrome often represents systemic disorders such as arthralgia, rash, prolonged fever, anaemia and ocular symptoms that require medication incl...

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Bibliographic Details
Published in:CEN case reports 2018-11, Vol.7 (2), p.221-224
Main Author: Sugiyama, Masafumi
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - urine
Administration, Oral
beta 2-Microglobulin - urine
Biomarkers - urine
Case Report
Child
Female
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Medicine
Medicine & Public Health
Nephritis, Interstitial - complications
Nephritis, Interstitial - diagnosis
Nephritis, Interstitial - drug therapy
Nephritis, Interstitial - metabolism
Nephritis, Interstitial - urine
Nephrology
Prednisolone - administration & dosage
Prednisolone - adverse effects
Prednisolone - therapeutic use
Treatment Outcome
Urology
Uveitis - diagnosis
Uveitis - drug therapy
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Summary:Tubulointerstitial nephritis and uveitis (TINU) is a rare syndrome in which idiopathic interstitial nephritis coexists with chronic recurrent uveitis. This syndrome often represents systemic disorders such as arthralgia, rash, prolonged fever, anaemia and ocular symptoms that require medication including glucocorticoid administration. Recently, novel urinary biomarkers, such as kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and liver-type fatty acid-binding protein, were shown to be associated with tubulointerstitial damage and were elevated in interstitial nephritis. We evaluated these urinary biomarkers in a case of TINU syndrome before and during treatment and found that their levels were elevated at onset and decreased during treatment, especially NGAL. We conclude that these urinary biomarkers are useful to evaluate and predict prognosis in interstitial nephritis.
ISSN:2192-4449
2192-4449
DOI:10.1007/s13730-018-0330-5