G1m1 predominance of intrathecal virus‐specific antibodies in multiple sclerosis

We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 a...

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Bibliographic Details
Published in:Annals of clinical and translational neurology 2018-10, Vol.5 (10), p.1303-1309
Main Authors: Tomescu‐Baciu, Alina, Vartdal, Frode, Holmøy, Trygve, Vedeler, Christian A., Lossius, Andreas
Format: Article
Language:English
Subjects:
Brief Communication
Chicken pox
Multiple sclerosis
Vaccines
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Summary:We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotype in the intrathecal humoral immune responses against measles, rubella, and varicella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized varicella zoster virus‐specific IgG1 in varicella zoster virus meningoencephalitis comprised both allotypes. This implies that G1m1 B cells are selected to the central nervous system of multiple sclerosis patients regardless of specificity and suggests that an antigen‐independent mechanism could drive the intrathecal humoral immune response.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.642