Gall bladder mucoceles in Border terriers

Background Gall bladder mucoceles (GBM) are a leading cause of biliary disease in dogs with several breeds, including the Shetland Sheepdog, American Cocker Spaniel, Chihuahua, Pomeranian, and Miniature Schnauzer apparently predisposed. Objective To determine risk factors, clinical features, and res...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2018-09, Vol.32 (5), p.1618-1628
Main Authors: Allerton, F., Swinbourne, F., Barker, L., Black, V., Kathrani, A., Tivers, M., Henriques, T., Kisielewicz, C., Dunning, M., Kent, A.
Format: Article
Language:English
Subjects:
Animals
biliary disease
Case-Control Studies
cholecystectomy
Dog Diseases - genetics
Dog Diseases - pathology
Dogs
extrahepatic biliary tract obstruction
Gallbladder Diseases - genetics
Gallbladder Diseases - veterinary
Genetic Predisposition to Disease
hypercholesterolemia
liver
Mucocele - genetics
Mucocele - pathology
Mucocele - veterinary
Retrospective Studies
Risk Factors
SMALL ANIMAL
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Summary:Background Gall bladder mucoceles (GBM) are a leading cause of biliary disease in dogs with several breeds, including the Shetland Sheepdog, American Cocker Spaniel, Chihuahua, Pomeranian, and Miniature Schnauzer apparently predisposed. Objective To determine risk factors, clinical features, and response to treatment of GBM in Border terriers (BT). Animals Medical records of 99 dogs (including 51 BT) with an ultrasonographic (±histopathologic) diagnosis of GBM from three referral centers in the United Kingdom were collected. A control group of 87 similar‐aged BT with no ultrasonographic evidence of gall bladder disease was selected for comparison. Method Retrospective case‐control study. Odds ratios were calculated to establish breed predisposition. Signalment, presence of endocrine disease, clinicopathologic results, and outcome were compared between the BT, other breeds, and control BTs. Results The odds of identifying a GBM in a BT in this hospital population was 85 times that of all other breeds (95% confidence interval 56.9‐126.8). BT had similar clinical signs and clinicopathologic changes to other breeds with GBM. There was no evidence that endocrinopathies were associated with GBM in BT. Clinical Significance A robust breed predisposition to GBM is established for the BT.
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.15249