Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway

For centuries, the Chinese herb Cuscuta chinensis has been applied clinically for abortion prevention in traditional Chinese medicine (TCM). Total flavones extracted from Cuscuta chinensis (TFCC) are one of the active components in the herb and also display anti-abortion effect similar to the unproc...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Gao, Jie, Luo, Songping, Yang, Li-lin, Yu, Qing-ying, Qiu, Wei-yu, Wang, Dong-ying, Feng, Yi-hui, Wu, Hai-wang, Liang, Chun
Format: Article
Language:English
Subjects:
Abortion
Apoptosis
Bioflavonoids
Birth control
Cancer
Cell growth
Chinese medicine
Cuscuta chinensis
Decidua
Drug dosages
Estrogen receptors
Flavones
Flavonoids
Herbal medicine
Herbs
MAP kinase
Medicine, Chinese
Mifepristone
Miscarriage
Neurosciences
Physiology
Pregnancy
Pro-life movement
Progesterone
Prolactin
Rodents
Signal transduction
Traditional Chinese medicine
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Summary:For centuries, the Chinese herb Cuscuta chinensis has been applied clinically for abortion prevention in traditional Chinese medicine (TCM). Total flavones extracted from Cuscuta chinensis (TFCC) are one of the active components in the herb and also display anti-abortion effect similar to the unprocessed material. However, how TFCC exerts the anti-abortion effect remains largely unknown. In this study, we aim at characterizing the anti-abortion effects of TFCC and its underlying molecular mechanism in vitro and in vivo using human primary decidua cells and a mifepristone-induced abortion model in rat, respectively. The damage to the decidua caused by mifepristone in vivo was reversed by TFCC treatment in a dosage-dependent manner. High dosage of TFCC significantly upregulated the expression of estrogen receptor (ER), progesterone receptor (PR), and prolactin receptor (PRLR) in decidua tissue but downregulated the expression of p-ERK. Furthermore, we detected higher level of p-ERK and p-p38 in primary decidua cells from spontaneous abortion while treatment by TFCC downregulated their expression. Our results suggest TFCC mediates its anti-abortion effect by interfering with MAPK signaling pathway.
ISSN:1741-427X
1741-4288
DOI:10.1155/2018/6356190