Pharmacokinetics of β‑Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new β-lactam antibiotics with su...

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Bibliographic Details
Published in:ACS infectious diseases 2018-10, Vol.4 (10), p.1439-1447
Main Authors: Smith, Paul W., Zuccotto, Fabio, Bates, Robert H., Martinez-Martinez, Maria Santos, Read, Kevin D., Peet, Caroline, Epemolu, Ola
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
beta-Lactams - administration & dosage
beta-Lactams - classification
beta-Lactams - pharmacokinetics
beta-Lactams - therapeutic use
Biological Availability
Cell Membrane Permeability - drug effects
Drug Discovery - methods
Half-Life
Haplorhini
Humans
Mycobacterium tuberculosis - drug effects
Protein Binding
Retrospective Studies
Solubility
Treatment Outcome
Tuberculosis - drug therapy
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Summary:β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new β-lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently, the historical β-lactam pharmacokinetic data have been compiled and analyzed to identify possible directions and drug discovery strategies aimed toward new β-lactam antibiotics with this profile.
ISSN:2373-8227
2373-8227
DOI:10.1021/acsinfecdis.8b00160