Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside

The incidence of serious fungal infections is increasing rapidly, and yet the rate of new drugs becoming available to treat them is slow. The limited therapeutic armamentarium is a challenge for clinicians, because the available drugs are often toxic, expensive, difficult to administer, ineffective...

Full description

Saved in:
Bibliographic Details
Published in:Future microbiology 2018-08, Vol.13 (10), p.1175-1191
Main Authors: Beardsley, Justin, Halliday, Catriona L, Chen, Sharon C-A, Sorrell, Tania C
Format: Article
Language:English
Subjects:
Antifungal agents
Antifungal Agents - pharmacology
Aspergillus - classification
Aspergillus - drug effects
Aspergillus - genetics
Aspergillus - physiology
Azoles
Azoles - pharmacology
Candida - classification
Candida - drug effects
Candida - genetics
Candida - physiology
Clinical outcomes
Disease
Drug resistance
Drug Resistance, Fungal - genetics
Drug Resistance, Fungal - physiology
Echinocandins
Echinocandins - pharmacology
Enzymes
Epidemiology
Fungal infections
Genes
Hematology
Humans
Microbiological Techniques
Models, Biological
Mortality
Mutation
Mycoses - diagnosis
Mycoses - drug therapy
Mycoses - epidemiology
Oncology
Patients
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The incidence of serious fungal infections is increasing rapidly, and yet the rate of new drugs becoming available to treat them is slow. The limited therapeutic armamentarium is a challenge for clinicians, because the available drugs are often toxic, expensive, difficult to administer, ineffective or a combination of all four. Given this setting, the emergence of resistance is especially concerning, and a review of the topic is timely. Here we discuss antifungal drug resistance in spp. and spp. with reference to the most commonly used first-line antifungal agents - azoles and echinocandins. We review the resistance mechanisms of the leading pathogens, how resistance can be identified in the diagnostic lab and the clinical implications of resistance once detected.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2018-0059